ArticleComputer methods in biomechanics and biomedical engineering2014
An integrated approach to patient-specific predictive modeling for single ventricle heart palliation.
Article in Computer methods in biomechanics and biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Surgical planning of the total cavopulmonary connection: robustness analysis.Annals of biomedical engineering · 2015Trial
- Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications.Engineering with computers · 2026Article
- Single ventricle care: challenges, successes and the future in a single center program.Translational pediatrics · 2025Review
- Prediction of Right Heart Failure in LVAD Candidates: Current Approaches and Future Directions.Journal of cardiovascular development and disease · 2025Review
- Differences in Exercise Performance in Fontan Patients with Extracardiac Conduit and Lateral Tunnel: A FORCE Fontan Registry Study.Journal of clinical medicine · 2025Article
- Computer-generated Clinical Decision-making in the Treatment of Pulmonary Atresia with Intact Ventricular Septum.Cardiovascular engineering and technology · 2025Article
- Computational Fluid Dynamic Assessment of Patients with Congenital Heart Disease from 3D Rotational Angiography.Pediatric cardiology · 2025Article
- Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.Cardiovascular engineering and technology · 2024Article
- Differences in Pulmonary and Systemic Flow Measurements by Cardiac Magnetic Resonance vs Cardiac Catheterization and Relation to Collateral Flow in Single Ventricle Patients.Pediatric cardiology · 2020Article
- Numerical Simulation of the Effect of Pulmonary Vascular Resistance on the Hemodynamics of Reoperation After Failure of One and a Half Ventricle Repair.Frontiers in physiology · 2020Article
- Dobutamine stress testing in patients with Fontan circulation augmented by biomechanical modeling.PloS one · 2020Article
- Factors Affecting Cardiovascular Physiology in Cardiothoracic Surgery: Implications for Lumped-Parameter Modeling.Frontiers in surgery · 2019Review
- Patient-Specific Cardiovascular Computational Modeling: Diversity of Personalization and Challenges.Journal of cardiovascular translational research · 2018Review
- Fontan Surgical Planning: Previous Accomplishments, Current Challenges, and Future Directions.Journal of cardiovascular translational research · 2018Review
- Lumped parameter model for hemodynamic simulation of congenital heart diseases.The journal of physiological sciences : JPS · 2018Review
- Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities.Frontiers in physiology · 2018Review
- Tetralogy of Fallot Surgical Repair: Shunt Configurations, Ductus Arteriosus and the Circle of Willis.Cardiovascular engineering and technology · 2017Article
- Patient-specific parameter estimation in single-ventricle lumped circulation models under uncertainty.International journal for numerical methods in biomedical engineering · 2017Article
- Computational modelling for congenital heart disease: how far are we from clinical translation?Heart (British Cardiac Society) · 2017Review
- Inverse problems in reduced order models of cardiovascular haemodynamics: aspects of data assimilation and heart rate variability.Journal of the Royal Society, Interface · 2017Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
In patients with congenital heart disease and a single ventricle (SV), ventricular support of the circulation is inadequate, and staged palliative surgery (usually 3 stages) is needed for treatment. In the various palliative surgical stages individual differences in the circulation are important and patient-specific surgical planning is ideal. In this study, an integrated approach between clinicians and engineers has been developed, based on patient-specific multi-scale models, and is here applied to predict stage 2 surgical outcomes. This approach involves four distinct steps: (1) collection of pre-operative clinical data from a patient presenting for SV palliation, (2) construction of the pre-operative model, (3) creation of feasible virtual surgical options which couple a three-dimensional model of the surgical anatomy with a lumped parameter model (LPM) of the remainder of the circulation and (4) performance of post-operative simulations to aid clinical decision making. The pre-operative model is described, agreeing well with clinical flow tracings and mean pressures. Two surgical options (bi-directional Glenn and hemi-Fontan operations) are virtually performed and coupled to the pre-operative LPM, with the hemodynamics of both options reported. Results are validated against postoperative clinical data. Ultimately, this work represents the first patient-specific predictive modeling of stage 2 palliation using virtual surgery and closed-loop multi-scale modeling.
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