ArticleCardiovascular diabetology2013
Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Association between osteocalcin and glucose metabolism: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Pooled it
- Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease.Journal of biomedical science · 2015Trial
- Emerging Circulating Biomarkers for Enhanced Cardiovascular Risk Prediction.Journal of lipid and atherosclerosis · 2024Review
- Vitamin K and Calcium Chelation in Vascular Health.Biomedicines · 2023Review
- Association of bone turnover biomarkers with severe intracranial and extracranial artery stenosis in type 2 diabetes mellitus patients.World journal of diabetes · 2023Article
- Age- and sex-specific differences in the association of serum osteocalcin and cardiometabolic risk factors in type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- Does Serum Osteocalcin Level Affect Carotid Atherosclerosis in Post-Menopausal Diabetic Females? A Case-Control Study.International journal of general medicine · 2022Article
- Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus.Frontiers in cardiovascular medicine · 2022Article
- Recognized and Potentially New Biomarkers-Their Role in Diagnosis and Prognosis of Cardiovascular Disease.Medicina (Kaunas, Lithuania) · 2021Review
- Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review).Molecular medicine reports · 2019Review
- Nontraditional Cardiovascular Biomarkers and Risk Factors: Rationale and Future Perspectives.Biomolecules · 2018Review
- High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes.Cardiovascular diabetology · 2017Article
- Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women.Journal of bone metabolism · 2017Article
- Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis.Frontiers in endocrinology · 2017Article
- Premature Atherosclerosis and Drug Eluting Stent Restenosis in an Adult with Osteogenesis Imperfecta.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016Article
- Association of Serum Osteocalcin with Insulin Resistance and Coronary Atherosclerosis.Journal of bone metabolism · 2016Article
- An overview of osteocalcin progress.Journal of bone and mineral metabolism · 2016Review
- Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population.Cardiovascular diabetology · 2015Article
- Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein.Cardiovascular diabetology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.
methodsWe performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.
resultsThe crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all P<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.
conclusionsSerum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.