ArticleMarine drugs2012
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model.
Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- RETRACTION: Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer.BioMed research international · 2026Article
- RETRACTION: Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model.Mediators of inflammation · 2026Article
- Influence of Degree of Polymerization of Low-Molecular-Weight Chitosan Oligosaccharides on the α-Glucosidase Inhibition.Molecules (Basel, Switzerland) · 2022Article
- Pyridine-Based NNS Tridentate Chitosan Thiosemicarbazones and Their Copper(II) Complexes: Synthesis, Characterization, and Anticancer Activity.ACS omega · 2022Article
- Chemopreventive Efficacy of Thymoquinone in Chemically Induced Urinary Bladder Carcinogenesis in Rat.BioMed research international · 2022Article
- Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery.Antioxidants (Basel, Switzerland) · 2021Review
- Characterization of a New Chitosanase from a Marine Bacillus sp. and the Anti-Oxidant Activity of Its Hydrolysate.Marine drugs · 2020Article
- Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects.Marine drugs · 2019Review
- Chitosan Oligosaccharide Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Mice.Marine drugs · 2019Article
- Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritional Supplements of Cancer Adjuvant Therapy.International journal of molecular sciences · 2019Article
- Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis.Marine drugs · 2018Article
- Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action.International journal of biomaterials · 2018Review
- Anticoccidial activities of Chitosan on Eimeria papillata-infected mice.Parasitology research · 2016Article
- Chitooligosaccharides promote radiosensitivity in colon cancer line SW480.World journal of gastroenterology · 2016Article
- Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats.Marine drugs · 2015Article
- Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-κB and endothelial inflammatory response.Carbohydrate polymers · 2014Article
- Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.