ArticleCancer medicine2012
Identification of multiple subclones in peripheral T-cell lymphoma, not otherwise specified with genomic aberrations.
Article in Cancer medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Antibody-Based Therapies for Peripheral T-Cell Lymphoma.Cancers · 2024Review
- Clinical Applications of Genomic Alterations in ATLL: Predictive Markers and Therapeutic Targets.Cancers · 2021Review
- Clinicopathological analysis in PTCL-NOS with CADM1 expression.Virchows Archiv : an international journal of pathology · 2017Article
- Romidepsin for the Treatment of Peripheral T-Cell Lymphoma.The oncologist · 2015Review
- Incidence of adult T-cell leukemia/lymphoma in nonendemic areas.Current treatment options in oncology · 2015Review
- Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.Cancer science · 2014Article
- Romidepsin for the Treatment of Peripheral T-Cell Lymphoma.Journal of the advanced practitioner in oncologyReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with genomic aberrations has been shown to resemble lymphoma-type adult T-cell leukemia/lymphoma (ATLL) in terms of its genomic aberration patterns, histopathology, and prognosis. We have shown recently that a majority of patients with acute-type ATLL have multiple subclones that were likely produced in lymph nodes. In this study, we analyzed whether PTCL, NOS with genomic aberrations also has multiple subclones as found in ATLL by means of high-resolution oligo-array comparative genomic hybridization (CGH). Thirteen cases of PTCL, NOS were available for 44K high-resolution array CGH analysis. The results showed that 11 (84.6%) of the 13 cases had a log2 ratio imbalance, suggesting that multiple subclones exist in PTCL, NOS with genomic aberrations. In order to analyze the association between multiple subclones and prognosis, we used previous bacterial-artificial chromosome (BAC) array analyses for 29 cases and found that the existence of multiple subclones was associated with a poor prognosis (P = 0.0279).
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Registered trials
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