ArticlePloS one2013
Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Higher risk of metabolic syndrome in children and adolescents and polymorphisms in the fat mass and obesity-associated gene: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Genetic Variants in the Fat Mass and Obesity-Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2024Pooled it
- FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Genetics of Common Obesity in Children and Adolescents.Annals of the New York Academy of Sciences · 2025Review
- Protective Association of APOC1/rs4420638 with Risk of Obesity: A case-control Study in Portuguese Children.Biochemical genetics · 2024Article
- Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome.Nutrients · 2023Review
- Minor alleles ofFrontiers in endocrinology · 2023Article
- Genetics, epigenetics and transgenerational transmission of obesity in children.Frontiers in endocrinology · 2022Review
- Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.PloS one · 2022Article
- Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents.Journal of pediatric genetics · 2021Article
- Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals.Eating and weight disorders : EWD · 2020Article
- Intergenerational transmission of the effects of maternal exposure to childhood maltreatment on offspring obesity risk: A fetal programming perspective.Psychoneuroendocrinology · 2020Review
- Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females.International journal of general medicine · 2020Article
- The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Relationship Between Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms with Obesity and Metabolic Syndrome in Ethnic Mongolians.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.Endocrine · 2018Article
- Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents.Genes & diseases · 2017Article
- Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.Journal of cachexia, sarcopenia and muscle · 2017Article
- Risk of obesity and metabolic syndrome associated with FTO gene variants discloses clinically relevant gender difference among Turks.Molecular biology reports · 2016Article
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3 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundSeveral studies have reported an association between single nucleotide polymorphisms in the first intron of the FTO gene and body mass index (BMI) or obesity. However, this association has not yet been studied among the Portuguese population. This study aims to assess the association of three FTO polymorphisms (rs1861868, rs1421085 and rs9939609) with obesity-related outcomes in a sample of Portuguese children.
methodsWe examined a total of 730 children, 256 normal-weight (55.9% girls), 320 overweight (45.3% girls) and 154 obese (53.2% girls), aging from 6 to 12-years-old, recruited randomly from public schools in the central region of Portugal. DNA samples were genotyped for the three polymorphisms by allelic discrimination TaqMan assay. Association of the FTO polymorphisms with several anthropometric traits was investigated. Additionally, we tested association with the risk of obesity using overweight and obese vs. normal-weight children.
resultsWe found significant associations of rs9939609 and rs1421085 polymorphisms with weight, BMI, BMI Z-score, waist circumference and hip circumference, even after age and gender adjustment (p<0.05 in all traits). For rs1861868 polymorphism, marginally significant associations were obtained with weight (p = 0.081) and BMI (p = 0.096) after adjustment for age and gender. In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05). Haplotype analyses identified two combinations (ACA and GCA) associated with a higher risk of obesity (OR 1.53; 95% CI, 1.06-2.22; p = 0.023; OR 1.73; 95% CI, 1.06-2.87; p = 0.030, respectively).
conclusionsThis study provides the first evidence for the association of FTO polymorphisms with anthropometric traits and risk of obesity in Portuguese children.
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