ArticlePloS one2013
Transcriptome of Dickeya dadantii infecting Acyrthosiphon pisum reveals a strong defense against antimicrobial peptides.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- When Small Meets Smaller: Immune Modulation and Virulence Strategies in Insect-Bacteria Interactions.Insects · 2026Review
- Entomopathogenic Bacteria Species and Toxins Targeting Aphids (Hemiptera: Aphididae): A Review.Plants (Basel, Switzerland) · 2025Review
- Comparative analyses of RNA-seq and phytohormone data of sweetpotatoes inoculated with Dickeya dadantii causing bacterial stem and root rot of sweetpotato.BMC plant biology · 2024Article
- Genetic Loci of Plant PathogenicInternational journal of molecular sciences · 2024Article
- Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp.Microbiome · 2023Article
- Characterization of the Arn lipopolysaccharide modification system essential for zeamine resistance unveils its new roles in Dickeya oryzae physiology and virulence.Molecular plant pathology · 2023Article
- Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system.Microbiome · 2022Article
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- Genome Wide Mapping of Peptidases inFrontiers in physiology · 2017Article
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- Entomopathogenicity to Two Hemipteran Insects Is Common but Variable across EpiphyticFrontiers in plant science · 2017Article
- Antimicrobial Peptide Resistance Genes in the Plant Pathogen Dickeya dadantii.Applied and environmental microbiology · 2016Article
- A highly infective plant-associated bacterium influences reproductive rates in pea aphids.Royal Society open science · 2016Article
- Role of Dickeya dadantii 3937 chemoreceptors in the entry to Arabidopsis leaves through wounds.Molecular plant pathology · 2015Article
- Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides.Frontiers in microbiology · 2013Review
- D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing.Journal of bacteriology · 2013Article
- Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers.Macromolecular bioscience · 2013Article
- Article
- Promise for plant pest control: root-associated pseudomonads with insecticidal activities.Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant pathogenic bacterium Dickeya dadantii has recently been shown to be able to kill the aphid Acyrthosiphon pisum. While the factors required to cause plant disease are now well characterized, those required for insect pathogeny remain mostly unknown. To identify these factors, we analyzed the transcriptome of the bacteria isolated from infected aphids. More than 150 genes were upregulated and 300 downregulated more than 5-fold at 3 days post infection. No homologue to known toxin genes could be identified in the upregulated genes. The upregulated genes reflect the response of the bacteria to the conditions encountered inside aphids. While only a few genes involved in the response to oxidative stress were induced, a strong defense against antimicrobial peptides (AMP) was induced. Expression of a great number of efflux proteins and transporters was increased. Besides the genes involved in LPS modification by addition of 4-aminoarabinose (the arnBCADTEF operon) and phosphoethanolamine (pmrC, eptB) usually induced in Gram negative bacteria in response to AMPs, dltBAC and pbpG genes, which confer Gram positive bacteria resistance to AMPs by adding alanine to teichoic acids, were also induced. Both types of modification confer D. dadantii resistance to the AMP polymyxin. A. pisum harbors symbiotic bacteria and it is thought that it has a very limited immune system to maintain these populations and do not synthesize AMPs. The arnB mutant was less pathogenic to A. pisum, which suggests that, in contrast to what has been supposed, aphids do synthesize AMP.
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Registered trials
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