ArticlePloS one2013
A secretory protein of necrotrophic fungus Sclerotinia sclerotiorum that suppresses host resistance.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 166 citations in OpenAlex.
- Antifungal Activity and Biochemical Mechanisms of Artemisinin Against the PhytopathogenInternational journal of molecular sciences · 2026Article
- Article
- The Velvet Complex Is Essential for Sclerotia Formation and Virulence inJournal of fungi (Basel, Switzerland) · 2025Article
- NtCML19 Is Recruited by Tobacco to Interact With the Deacetylase Protein RsDN3377 of Rhizoctonia solani AG3-TB, Inhibiting Fungal Infection.Molecular plant pathology · 2025Article
- To immunity and beyond: the central role of jasmonate signalling in beneficial root-microbe-environment interactions.The New phytologist · 2025Review
- Article
- Validation ofJournal of fungi (Basel, Switzerland) · 2025Article
- Comparative insights into soybean and other oilseed crops' defense mechanisms againstFrontiers in plant science · 2025Review
- Targeting effector proteins of plant pathogens as a strategy for durable plant disease resistance.Frontiers in microbiology · 2025Article
- Efficacy ofInternational journal of molecular sciences · 2024Article
- The Role of Salicylic, Jasmonic Acid and Ethylene in the Development of the Resistance/Susceptibility of Wheat to the SnTox1-Producing Isolate of the Pathogenic FungusPlants (Basel, Switzerland) · 2024Article
- An effector SsCVNH promotes the virulence of Sclerotinia sclerotiorum through targeting class III peroxidase AtPRX71.Molecular plant pathology · 2024Article
- Histone MethyltransferaseJournal of fungi (Basel, Switzerland) · 2024Article
- The schizotrophic lifestyle of Sclerotinia sclerotiorum.Molecular plant pathology · 2024Review
- Variable Tandem Glycine-Rich Repeats Contribute to Cell Death-Inducing Activity of a Glycosylphosphatidylinositol-Anchored Cell Wall Protein That Is Associated with the Pathogenicity of Sclerotinia sclerotiorum.Microbiology spectrum · 2023Article
- Review
- Review
- Genetic breakthroughs in theFrontiers in plant science · 2023Review
- Fungal effectors versus defense-related genes ofFrontiers in plant science · 2023Review
- Nitrate reductase is required for sclerotial development and virulence ofFrontiers in plant science · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SSITL (SS1G_14133) of Sclerotinia sclerotiorum encodes a protein with 302 amino acid residues including a signal peptide, its secretion property was confirmed with immunolocalization and immunofluorescence techniques. SSITL was classified in the integrin alpha N-terminal domain superfamily, and its 3D structure is similar to those of human integrin α4-subunit and a fungal integrin-like protein. When S. sclerotiorum was inoculated to its host, high expression of SSITL was detected during the initial stages of infection (1.5-3.0 hpi). Targeted silencing of SSITL resulted in a significant reduction in virulence; on the other hand, inoculation of SSITL silenced transformant A10 initiated strong and rapid defense response in Arabidopsis, the highest expressions of defense genes PDF1.2 and PR-1 appeared at 3 hpi which was 9 hr earlier than that time when plants were inoculated with the wild-type strain of S. sclerotiorum. Systemic resistance induced by A10 was detected by analysis of the expression of PDF1.2 and PR-1, and confirmed following inoculation with Botrytis cinerea. A10 induced much larger lesions on Arabidopsis mutant ein2 and jar1, and slightly larger lesions on mutant pad4 and NahG in comparison with the wild-type plants. Furthermore, both transient and constitutive expression of SSITL in Arabidopsis suppressed the expression of PDF1.2 and led to be more susceptible to A10 and the wild-type strain of S. sclerotiorum and B. cinerea. Our results suggested that SSITL is an effector possibly and plays significant role in the suppression of jasmonic/ethylene (JA/ET) signal pathway mediated resistance at the early stage of infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.