ArticlePloS one2013
The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host's cell vimentin.Parasitology research · 2022Article
- Reduced IFN-ß inhibitory activity of Lagos bat virus phosphoproteins in human compared to Eidolon helvum bat cells.PloS one · 2022Article
- Zoonotic and reverse zoonotic transmission of viruses between humans and pigs.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Review
- Antagonism of STAT3 signalling by Ebola virus.PLoS pathogens · 2021Article
- Evolutionary history of cotranscriptional editing in the paramyxoviral phosphoprotein gene.Virus evolution · 2021Review
- The Dynamic Interface of Viruses with STATs.Journal of virology · 2020Review
- Lyssavirus P-protein selectively targets STAT3-STAT1 heterodimers to modulate cytokine signalling.PLoS pathogens · 2020Article
- A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.Viruses · 2019Article
- MicroRNA Expression Profiling in Behçet's Disease.Journal of immunology research · 2018Article
- Gene Expression Profiling in Behcet's Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy.Journal of immunology research · 2018Article
- Immune Response toJournal of immunology research · 2018Article
- Article
- Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns.Advances in virus research · 2017Review
- Gene Expression Profiling in Peripheral Blood Cells and Synovial Membranes of Patients with Psoriatic Arthritis.PloS one · 2015Article
- High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.Journal of visualized experiments : JoVE · 2014Article
- The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capacity of a virus to cross species barriers is determined by the development of bona fide interactions with cellular components of new hosts, and in particular its ability to block IFN-α/β antiviral signaling. Tioman virus (TioV), a close relative of mumps virus (MuV), has been isolated in giant fruit bats in Southeast Asia. Nipah and Hendra viruses, which are present in the same bat colonies, are highly pathogenic in human. Despite serological evidences of close contacts between TioV and human populations, whether TioV is associated to some human pathology remains undetermined. Here we show that in contrast to the V protein of MuV, the V protein of TioV (TioV-V) hardly interacts with human STAT2, does not degrade STAT1, and cannot block IFN-α/β signaling in human cells. In contrast, TioV-V properly binds to human STAT3 and MDA5, and thus interferes with IL-6 signaling and IFN-β promoter induction in human cells. Because STAT2 binding was previously identified as a host restriction factor for some Paramyxoviridae, we established STAT2 sequence from giant fruit bats, and binding to TioV-V was tested. Surprisingly, TioV-V interaction with STAT2 from giant fruit bats is also extremely weak and barely detectable. Altogether, our observations question the capacity of TioV to appropriately control IFN-α/β signaling in both human and giant fruit bats that are considered as its natural host.
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