ArticlePloS one2013
The pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strains.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 131 citations in OpenAlex.
- Pangenomic and genomic plasticity analyses of the genus Rickettsia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Genomic Characterization and Pathogenicity Island Analysis of 17 Mexican Isolates ofCurrent issues in molecular biology · 2026Article
- Genomic diversity and host-specificity inFrontiers in microbiology · 2026Article
- The pangenome: a statistical model, not a fixed biological property.Bioinformatics advances · 2026Review
- Hidden in the Pangenome? Machine Learning-Driven Discovery of Antimicrobial Potential inBioinformatics and biology insights · 2026Article
- Comparative pangenomics of theFrontiers in microbiology · 2026Article
- Caseous Lymphadenitis Outbreak in Dairy Cattle: Clinical Findings, Management, and Autogenous Vaccine Development.Veterinary sciences · 2025Article
- Multiscale comparative pathogenomic analysis of Vibrio anguillarum linking serotype diversity, genomic plasticity and pathogenicity.Journal, genetic engineering & biotechnology · 2025Article
- Pathogenomic Insights intoAnimals : an open access journal from MDPI · 2025Article
- Benchmarking pangenome dynamics and horizontal gene transfer inFrontiers in microbiology · 2025Article
- Ovine and Caprine Strains ofMicroorganisms · 2024Article
- Article
- Corynebacterium pseudotuberculosis: Whole genome sequencing reveals unforeseen and relevant genetic diversity in this pathogen.PloS one · 2024Article
- Pangenome analysis of Corynebacterium striatum: insights into a neglected multidrug-resistant pathogen.BMC microbiology · 2023Article
- Molecular Characterization and Antimicrobial Susceptibilities ofAnimals : an open access journal from MDPI · 2023Article
- Comparative Characterization of Immune Response in Sheep with Caseous Lymphadenitis through Analysis of the Whole Blood Transcriptome.Animals : an open access journal from MDPI · 2023Article
- Dietary Epimedium extract supplementation improves intestinal functions and alters gut microbiota in broilers.Journal of animal science and biotechnology · 2023Article
- Pilot study on the distribution of caseous lymphadenitis in Korean native goats and the relationship between sex and age in disease occurrence.Frontiers in veterinary science · 2023Article
- Multi-Omics ofProteomes · 2022Article
- Relevance of prokaryotic subspecies in the age of genomics.New microbes and new infections · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corynebacterium pseudotuberculosis is a facultative intracellular pathogen and the causative agent of several infectious and contagious chronic diseases, including caseous lymphadenitis, ulcerative lymphangitis, mastitis, and edematous skin disease, in a broad spectrum of hosts. In addition, Corynebacterium pseudotuberculosis infections pose a rising worldwide economic problem in ruminants. The complete genome sequences of 15 C. pseudotuberculosis strains isolated from different hosts and countries were comparatively analyzed using a pan-genomic strategy. Phylogenomic, pan-genomic, core genomic, and singleton analyses revealed close relationships among pathogenic corynebacteria, the clonal-like behavior of C. pseudotuberculosis and slow increases in the sizes of pan-genomes. According to extrapolations based on the pan-genomes, core genomes and singletons, the C. pseudotuberculosis biovar ovis shows a more clonal-like behavior than the C. pseudotuberculosis biovar equi. Most of the variable genes of the biovar ovis strains were acquired in a block through horizontal gene transfer and are highly conserved, whereas the biovar equi strains contain great variability, both intra- and inter-biovar, in the 16 detected pathogenicity islands (PAIs). With respect to the gene content of the PAIs, the most interesting finding is the high similarity of the pilus genes in the biovar ovis strains compared with the great variability of these genes in the biovar equi strains. Concluding, the polymerization of complete pilus structures in biovar ovis could be responsible for a remarkable ability of these strains to spread throughout host tissues and penetrate cells to live intracellularly, in contrast with the biovar equi, which rarely attacks visceral organs. Intracellularly, the biovar ovis strains are expected to have less contact with other organisms than the biovar equi strains, thereby explaining the significant clonal-like behavior of the biovar ovis strains.
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