Trial reportPloS one2013
Serum vitamin D in patients with chronic obstructive lung disease does not correlate with mortality--results from a 10-year prospective cohort study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2016Pooled it
- Vitamin D status and chronic obstructive pulmonary disease risk: a prospective UK Biobank study.BMJ open respiratory research · 2023Article
- Gender Differences in Vitamin D Status and Determinants of Vitamin D Insufficiency in Patients with Chronic Obstructive Pulmonary Disease.Nutrients · 2023Observational
- Article
- Observational
- Airway obstruction, serum vitamin D and mortality in a 33-year follow-up study.European journal of clinical nutrition · 2019Article
- Low concentrations of 25-hydroxyvitamin D and long-term prognosis of COPD: a prospective cohort study.European journal of epidemiology · 2018Article
- Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD.International journal of chronic obstructive pulmonary disease · 2016Article
- Article
- Lung function, 25-hydroxyvitamin D concentrations and mortality in US adults.European journal of clinical nutrition · 2015Article
- Article
- Article
- Does low vitamin D amplify the association of COPD with total and cardiovascular disease mortality?Clinical cardiology · 2014Article
- Article
- Prognostic value of C-reactive protein, leukocytes, and vitamin d in severe chronic obstructive pulmonary disease.TheScientificWorldJournal · 2014Article
- Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.PloS one · 2014Article
- A review of Vitamin D effects on common respiratory diseases: Asthma, chronic obstructive pulmonary disease, and tuberculosis.Journal of research in pharmacy practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have found vitamin D (25-OHD) deficiency and insufficiency to be common among patients with COPD. Serum level of 25-OHD seems to correlate to pulmonary function, COPD disease staging, and increased susceptibility to respiratory infections. We wanted to investigate whether vitamin D deficiency or insufficiency was associated with mortality rate in patients suffering from advanced COPD.
methods25-OHD serum levels were measured in 462 patients suffering from moderate to very severe COPD. Patients were stratified into three groups according to serum levels of 25-OHD. Outcome measure was mortality in a 10 year follow-up period. Kaplan-Meier curves (KM) were plotted and mortality hazard ratios (HR) were calculated using Cox Proportional Hazard regression (Cox PH).
resultsSerum 25-OHD deficiency and insufficiency were prevalent. We were unable to demonstrate any association between baseline serum levels of 25-OHD and mortality rate. We found an association between mortality and age [HR 1.05 (CI 95%: 1.03-1.06)], Charlson score [HR 1.49 (CI 95%: 1.06-2.09)], increasing neutrophil count [HR 1.05 (CI 95%: 1.02-1.09)], severe [HR 1.41 (CI 95%: 1.06-1.86)]/very severe COPD [HR 2.19 (CI 95%: 1.58-3.02)] and a smoking history of more than 40 pack years [HR 1.27 (CI 95%: 1.02-1.70)].
conclusionsSerum level of 25-OHD does not seem to be associated with mortality rate, suggesting no or only a minor role of 25-OHD in disease progression in patients with moderate to very severe COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.