ArticlePloS one2013
Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Hemispheric lateralization of semantic processing before and after aripiprazole treatment in first-episode psychosis or ultra-high risk state.Schizophrenia (Heidelberg, Germany) · 2022Article
- A large-scale estimate on the relationship between language and motor lateralization.Scientific reports · 2020Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
- Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1.Molecular neurobiology · 2018Article
- Myelin Genes and the Corpus Callosum: Proteolipid Protein 1 (PLP1) and Contactin 1 (CNTN1) Gene Variation Modulates Interhemispheric Integration.Molecular neurobiology · 2017Article
- Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys.Brain structure & function · 2017Article
- Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries.eLife · 2017Article
- The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses.Frontiers in psychology · 2017Article
- Common Genetic Variant in VIT Is Associated with Human Brain Asymmetry.Frontiers in human neuroscience · 2016Article
- Linkage analysis in a Dutch population isolate shows no major gene for left-handedness or atypical language lateralization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The genetic relationship between handedness and neurodevelopmental disorders.Trends in molecular medicine · 2014Review
- Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease.BioFactors (Oxford, England)Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood. Therefore, the present study was aimed at investigating whether variation in schizophrenia-related genes modulates individual lateralization patterns. To this end, we genotyped 16 single nucleotide polymorphisms that have previously been linked to schizophrenia on a meta-analysis level in a sample of 444 genetically unrelated healthy participants and examined the association of these polymorphisms with handedness, footedness and language lateralization. We found a significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization assessed using the dichotic listening task. Individuals carrying the schizophrenia risk allele C of this polymorphism showed a marked reduction of the typical left-hemispheric dominance for language processing. Since the cholecystokinin A receptor is involved in dopamine release in the central nervous system, these findings suggest that genetic variation in this receptor may modulate language lateralization due to its impact on dopaminergic pathways.
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