ArticlePloS one2013
A genome-wide association study identifies genomic regions for virulence in the non-model organism Heterobasidion annosum s.s.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 76 citations in OpenAlex.
- Homothallic or Heterothallic? A Genomic Investigation Into the Sexual Capabilities of the Ascomycete Fungus Clonostachys rosea.Molecular ecology · 2026Article
- Genotype-by-genotype interactions reveal transcription patterns underlying resistance responses in Norway spruce to Heterobasidion annosum s.s.BMC plant biology · 2025Article
- Early-Stage Infection-SpecificInternational journal of molecular sciences · 2024Article
- Heritability and gene functions associated with sclerotia formation ofMicrobial genomics · 2023Article
- Multiple rearrangements and low inter- and intra-species mitogenome sequence variation in theFrontiers in microbiology · 2023Article
- Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect inMicrobiology spectrum · 2022Article
- New-Generation Sequencing Technology in Diagnosis of Fungal Plant Pathogens: A Dream Comes True?Journal of fungi (Basel, Switzerland) · 2022Review
- Genome-wide association and dissociation studies inFrontiers in microbiology · 2022Article
- Candidate Effectors ofFrontiers in microbiology · 2021Article
- Natural variation of root lesion nematode antagonism in the biocontrol fungusEvolutionary applications · 2020Article
- The conifer root rot pathogens Heterobasidion irregulare and Heterobasidion occidentale employ different strategies to infect Norway spruce.Scientific reports · 2020Article
- Plant-microbe Interactions for Sustainable Agriculture in the Post-genomic Era.Current genomics · 2020Review
- Genomic biosurveillance of forest invasive alien enemies: A story written in code.Evolutionary applications · 2020Review
- Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates ofFrontiers in fungal biology · 2020Article
- Population Genomics of Fungal Plant Pathogens and the Analyses of Rapidly Evolving Genome Compartments.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Correlating Genotype and Phenotype in the Asexual YeastG3 (Bethesda, Md.) · 2019Article
- Article
- Interactions of Tomato andThe Plant cell · 2019Article
- Genome-Wide Signatures of Selection inFrontiers in microbiology · 2019Article
- Characterization of Heterobasidion occidentale transcriptomes reveals candidate genes and DNA polymorphisms for virulence variations.Microbial biotechnology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dense single nucleotide polymorphisms (SNP) panels needed for genome wide association (GWA) studies have hitherto been expensive to establish and use on non-model organisms. To overcome this, we used a next generation sequencing approach to both establish SNPs and to determine genotypes. We conducted a GWA study on a fungal species, analysing the virulence of Heterobasidion annosum s.s., a necrotrophic pathogen, on its hosts Picea abies and Pinus sylvestris. From a set of 33,018 single nucleotide polymorphisms (SNP) in 23 haploid isolates, twelve SNP markers distributed on seven contigs were associated with virulence (P<0.0001). Four of the contigs harbour known virulence genes from other fungal pathogens and the remaining three harbour novel candidate genes. Two contigs link closely to virulence regions recognized previously by QTL mapping in the congeneric hybrid H. irregulare × H. occidentale. Our study demonstrates the efficiency of GWA studies for dissecting important complex traits of small populations of non-model haploid organisms with small genomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.