ArticlePatient preference and adherence2013
Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability.
Article in Patient preference and adherence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Recommendations for the community-based management of prolonged convulsive seizures in children in Europe.BMC pediatrics · 2026Guideline
- The administration of rescue medication to children with prolonged acute convulsive seizures in a non-hospital setting: an exploratory survey of healthcare professionals' perspectives.European journal of pediatrics · 2014Trial
- Fabrication and characterization of electrospun nanofibers using biocompatible polymers for the sustained release of venlafaxine.Scientific reports · 2022Article
- A Physiologically Based Pharmacokinetic Model for Predicting Diazepam Pharmacokinetics after Intravenous, Oral, Intranasal, and Rectal Applications.Pharmaceutics · 2021Article
- A Short Review on the Intranasal Delivery of Diazepam for Treating Acute Repetitive Seizures.Pharmaceutics · 2020Review
- Medical management of epileptic seizures: challenges and solutions.Neuropsychiatric disease and treatment · 2016Review
- Comparison of oral and buccal midazolam for pediatric dental sedation: a randomized, cross-over, clinical trial for efficacy, acceptance and safety.Iranian journal of pediatrics · 2014Article
- A comparison of the cost-effectiveness of treatment of prolonged acute convulsive epileptic seizures in children across Europe.Health economics review · 2014Article
- Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa.Asian Pacific journal of tropical biomedicine · 2013Article
- Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGReview
- Comparing the Sedative Effect of Oral and Intranasal Midazolam and their Effect on Behavior in Pediatric Dental Patients.International journal of clinical pediatric dentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged seizures and status epilepticus are a common acute neurological presentation in pediatric practice. As a result, there is a need for effective and safe medications that can be delivered to convulsing children to effect rapid seizure termination both in hospital and community settings. The challenges of achieving intravenous access, particularly in young children, mandate alternative routes of administration for these drugs. Over the last ten years, midazolam delivered via the buccal mucosa has been demonstrated to be efficacious, safe, and acceptable to children and their caregivers, and a formulation has recently been licensed for use in Europe. The aim of this article is to review the clinical pharmacology with respect to these issues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.