ArticleProceedings of the National Academy of Sciences of the United States of America2013
Generous economic investments after basolateral amygdala damage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.Journal of neurophysiology · 2026Article
- From hidden springs to endless oceans: exploring the complementary roles of the amygdala and hippocampus in phenomenal experience.Neuroscience of consciousness · 2026Article
- Steeper social discounting after human basolateral amygdala damage.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Prefrontal-Amygdala Pathways for Object and Social Value Representation.Journal of cognitive neuroscience · 2024Article
- Trust or Distrust: The Effect of Facial Emotion and Trustworthy Behavior on Trust Decision-Making.Psychologica Belgica · 2023Article
- Breakdown of utilitarian moral judgement after basolateral amygdala damage.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Provision of social support and mental health in U.S. military veterans.Npj mental health research · 2022Article
- Basolateral and central amygdala orchestrate how we learn whom to trust.Communications biology · 2021Article
- Neuronal Activity in the Primate Amygdala during Economic Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Connectome-based model predicts individual differences in propensity to trust.Human brain mapping · 2019Article
- Oxytocin Facilitates Social Learning by Promoting Conformity to Trusted Individuals.Frontiers in neuroscience · 2019Review
- Article
- Dispositional negativity: An integrative psychological and neurobiological perspective.Psychological bulletin · 2016Review
- Impaired acquisition of classically conditioned fear-potentiated startle reflexes in humans with focal bilateral basolateral amygdala damage.Social cognitive and affective neuroscience · 2015Article
- Self-reported impulsivity is negatively correlated with amygdalar volumes in cocaine dependence.Psychiatry research · 2015Article
- Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.Psychological bulletin · 2015Review
- Article
- A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology.The American journal of psychiatry · 2014Review
- Dissociable contributions of anterior cingulate cortex and basolateral amygdala on a rodent cost/benefit decision-making task of cognitive effort.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contemporary economic models hold that instrumental and impulsive behaviors underlie human social decision making. The amygdala is assumed to be involved in social-economic behavior, but its role in human behavior is poorly understood. Rodent research suggests that the basolateral amygdala (BLA) subserves instrumental behaviors and regulates the central-medial amygdala, which subserves impulsive behaviors. The human amygdala, however, typically is investigated as a single unit. If these rodent data could be translated to humans, selective dysfunction of the human BLA might constrain instrumental social-economic decisions and result in more impulsive social-economic choice behavior. Here we show that humans with selective BLA damage and a functional central-medial amygdala invest nearly 100% more money in unfamiliar others in a trust game than do healthy controls. We furthermore show that this generosity is not caused by risk-taking deviations in nonsocial contexts. Moreover, these BLA-damaged subjects do not expect higher returns or perceive people as more trustworthy, implying that their generous investments are not instrumental in nature. These findings suggest that the human BLA is essential for instrumental behaviors in social-economic interactions.
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