ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Gustducin couples fatty acid receptors to GLP-1 release in colon.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Signaling pathways in cancer metabolism: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Fatty Acid Sensing in the Gastrointestinal Tract of Rainbow Trout: Different to Mammalian Model?International journal of molecular sciences · 2023Article
- GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk.Microorganisms · 2022Review
- Taming the Sentinels: Microbiome-Derived Metabolites and Polarization of T Cells.International journal of molecular sciences · 2020Review
- Characterization of the taste receptor-related G-protein, α-gustducin, in pancreatic β-cells.Journal of diabetes investigation · 2020Article
- Chemogenetics defines receptor-mediated functions of short chain free fatty acids.Nature chemical biology · 2019Article
- Intestinal Sensing by Gut Microbiota: Targeting Gut Peptides.Frontiers in endocrinology · 2019Review
- Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.Pharmacology & therapeutics · 2016Review
- GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Recent advances in fatty acid perception and genetics.Advances in nutrition (Bethesda, Md.) · 2015Review
- The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice.PloS one · 2015Article
- The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon.Neurogastroenterology and motility · 2014Article
- Gut microbiota and GLP-1.Reviews in endocrine & metabolic disorders · 2014Review
- GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.Diabetologia · 2014Article
- Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.Molecular metabolism · 2014Article
- Regulation of Energy Homeostasis via GPR120.Frontiers in endocrinology · 2014Review
- Contributions of colonic short-chain Fatty Acid receptors in energy homeostasis.Frontiers in endocrinology · 2014Review
- Receptors for short-chain fatty acids in brush cells at the "gastric groove".Frontiers in physiology · 2014Article
- Article
- Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Molecular endocrinology (Baltimore, Md.) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sweet taste receptor subunits and α-gustducin found in enteroendocrine cells of the small intestine have been implicated in release of the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in response to glucose and noncaloric sweeteners. α-Gustducin has also been found in colon, although its function there is unclear. We examined expression of α-gustducin, GLP-1, and GIP throughout the intestine. The number of α-gustducin-expressing cells and those coexpressing α-gustducin together with GLP-1 and/or GIP increased from small intestine to colon. α-Gustducin also was coexpressed with fatty acid G protein-coupled receptor (GPR) 40, GPR41, GPR43, GPR119, GPR120, and bile acid G protein-coupled receptor TGR5 in enteroendocrine cells of the colon. In colon, GPR43 was coexpressed with GPR119 and GPR120, but not with TGR5. Treatment of colonic mucosa isolated from wild-type mice with acetate, butyrate, oleic acid, oleoylethanolamide, or lithocholic acid stimulated GLP-1 secretion. However, GLP-1 release in response to these fatty acids was impaired in colonic tissue from α-gustducin knockout mice.
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