ArticleNucleic acids research2013
Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava.Plant biotechnology journal · 2026Article
- Article
- Genome-wide identification, characterization, and expression analysis of MIPS family genes in legume species.BMC genomics · 2024Article
- A novel transcription factor SIPA1: identification and verification in triple-negative breast cancer.Oncogene · 2023Article
- Myo-inositol phosphate synthase improves heat stress tolerance by ethylene-mediated modulation of chlorophyll content and photosynthetic efficiency.Protoplasma · 2023Article
- Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae.Microbial cell factories · 2021Article
- The noncanonical role of the protease cathepsin D as a cofilin phosphatase.Cell research · 2021Article
- Role of myo-inositol during skotomorphogenesis in Arabidopsis.Scientific reports · 2020Article
- Wheat Myo-inositol phosphate synthase influences plant growth and stress responses via ethylene mediated signaling.Scientific reports · 2020Article
- Environmental impact of phytic acid in Maize (Physiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- The Arabidopsis lncRNA ASCO modulates the transcriptome through interaction with splicing factors.EMBO reports · 2020Article
- Phytic Acid and Transporters: What Can We Learn fromPlants (Basel, Switzerland) · 2020Review
- A Cotton (International journal of molecular sciences · 2019Article
- Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis.Plant molecular biology · 2018Article
- A review of redox signaling and the control of MAP kinase pathway in plants.Redox biology · 2017Review
- Chloroplast Activity and 3'phosphadenosine 5'phosphate Signaling Regulate Programmed Cell Death in Arabidopsis.Plant physiology · 2016Article
- Involvement of Inositol Biosynthesis and Nitric Oxide in the Mediation of UV-B Induced Oxidative Stress.Frontiers in plant science · 2016Article
- Seed Biofortification and Phytic Acid Reduction: A Conflict of Interest for the Plant?Plants (Basel, Switzerland) · 2015Review
- Involvement of Arabidopsis Hexokinase1 in Cell Death Mediated by Myo-Inositol Accumulation.The Plant cell · 2015Article
- Stress-induced chromatin changes in plants: of memories, metabolites and crop improvement.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because regulation of its activity is instrumental either to support cell proliferation and growth or to promote cell death, the universal myo-inositol phosphate synthase (MIPS), responsible for myo-inositol biosynthesis, is a critical enzyme of primary metabolism. Surprisingly, we found this enzyme to be imported in the nucleus and to interact with the histone methyltransferases ATXR5 and ATXR6, raising the question of whether MIPS1 has a function in transcriptional regulation. Here, we demonstrate that MIPS1 binds directly to its promoter to stimulate its own expression by locally inhibiting the spreading of ATXR5/6-dependent heterochromatin marks coming from a transposable element. Furthermore, on activation of pathogen response, MIPS1 expression is reduced epigenetically, providing evidence for a complex regulatory mechanism acting at the transcriptional level. Thus, in plants, MIPS1 appears to have evolved as a protein that connects cellular metabolism, pathogen response and chromatin remodeling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.