ArticleEuropean journal of human genetics : EJHG2013
Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial.Cardiovascular diabetology · 2016Trial
- Interplay between obesity-associated insulin resistance and immune system through the lens of evolutionary medicine.Molecular metabolism · 2026Review
- Unlocking Ethiopia's genomic landscape and its global significance: a call for inclusive genomics research.Human genomics · 2026Review
- Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Current obesity reports · 2024Review
- Food System Transformation and Gut Microbiota Transition: Evidence on Advancing Obesity, Cardiovascular Diseases, and Cancers-A Narrative Review.Foods (Basel, Switzerland) · 2023Review
- The PPARGC1A Is the Gene Responsible for Thrifty Metabolism Related Metabolic Diseases: A Scoping Review.Genes · 2022Article
- Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B.Biochemical genetics · 2021Article
- Analysis of genetic selection at insulin receptor substrate-2 gene loci.Journal of diabetes and metabolic disorders · 2021Article
- Evolutionary forces in diabetes and hypertension pathogenesis in Africans.Human molecular genetics · 2021Review
- Article
- Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study.Genetica · 2020Article
- Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A.BMC medical genetics · 2016Article
- The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.Journal of the American Society of Nephrology : JASN · 2016Article
- Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection.BMC genomics · 2016Article
- Heterospecific SNP diversity in humans and rhesus macaque (Macaca mulatta).Journal of medical primatology · 2015Article
- Digested wheat gluten inhibits binding between leptin and its receptor.BMC biochemistry · 2015Article
- Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation.International journal of organ transplantation medicine · 2015Article
- Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes.American journal of human genetics · 2014Article
- Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits.Current diabetes reports · 2014Review
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15 authors.
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Abstract
The high prevalence of type 2 diabetes and its uneven distribution among human populations is both a major public health concern and a puzzle in evolutionary biology. Why is this deleterious disease so common, while the associated genetic variants should be removed by natural selection? The 'thrifty genotype' hypothesis proposed that the causal genetic variants were advantageous and selected for during the majority of human evolution. It remains, however, unclear whether genetic data support this scenario. In this study, we characterized patterns of selection at 10 variants associated with type 2 diabetes, contrasting one herder and one farmer population from Central Asia. We aimed at identifying which alleles (risk or protective) are under selection, dating the timing of selective events, and investigating the effect of lifestyle on selective patterns. We did not find any evidence of selection on risk variants, as predicted by the thrifty genotype hypothesis. Instead, we identified clear signatures of selection on protective variants, in both populations, dating from the beginning of the Neolithic, which suggests that this major transition was accompanied by a selective advantage for non-thrifty variants. Combining our results with worldwide data further suggests that East Asia was particularly prone to such recent selection of protective haplotypes. As much effort has been devoted so far to searching for thrifty variants, we argue that more attention should be paid to the evolution of non-thrifty variants.
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