ArticleTranslational psychiatry2013
Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Prognostic Value of FasL, BDNF, and IL-1β as Predictors of Therapeutic Response in Schizophrenia.Journal of clinical medicine · 2025Article
- The role of snare proteins in cortical development.Developmental neurobiology · 2022Review
- The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior.Frontiers in cell and developmental biology · 2022Article
- Article
- Article
- Role of Munc18-1 in the biological functions and pathogenesis of neurological disorders (Review).Molecular medicine reports · 2021Review
- Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain.Neuroscience · 2019Article
- Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers in the Cerebrospinal Fluid of Patients with Sporadic Creutzfeldt-Jakob Disease.Molecular neurobiology · 2017Article
- Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.Scientific reports · 2017Article
- Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia.Current psychiatry reports · 2016Review
- Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample.Molecular neurodegeneration · 2015Article
- SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia.Biological psychiatry · 2015Article
- Increased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in Schizophrenia.Biological psychiatry · 2015Article
- Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain.Journal of neuroinflammation · 2014Article
- Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.The Journal of cell biology · 2014Article
- Discovery and functional assessment of gene variants in the vascular endothelial growth factor pathway.Human mutation · 2014Article
- STXBP1: fast-forward to a brighter future - a patient organization perspective.Therapeutic advances in rare diseaseReview
Corrections and comments
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Authors and funding
21 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter release. A transgenic mouse strain that overexpresses the protein isoform munc18-1a in the brain was characterized. This animal displays several schizophrenia-related behaviors, supersensitivity to hallucinogenic drugs and deficits in prepulse inhibition that reverse after antipsychotic treatment. Relevant brain areas (that is, cortex and striatum) exhibit reduced expression of dopamine D(1) receptors and dopamine transporters together with enhanced amphetamine-induced in vivo dopamine release. Magnetic resonance imaging demonstrates decreased gray matter volume in the transgenic animal. In conclusion, the mouse overexpressing brain munc18-1a represents a new valid animal model that resembles functional and structural abnormalities in patients with schizophrenia. The animal could provide valuable insights into phenotypic aspects of this psychiatric disorder.
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