ArticleTranslational psychiatry2013
Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment.
Article in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Epigenetic Modifications and Neuroplasticity in the Pathogenesis of Depression: A Focus on Early Life Stress.Behavioral sciences (Basel, Switzerland) · 2024Review
- The mediating role of transmembrane protein 132D methylation in predicting the occurrence of panic disorder in physical abuse.Frontiers in psychiatry · 2022Article
- Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function.Frontiers in aging neuroscience · 2022Article
- Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems.Frontiers in cell and developmental biology · 2022Review
- Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain.Annual review of pharmacology and toxicology · 2021Review
- DNA Methylation-Dependent Dysregulation of GABAergic Interneuron Functionality in Neuropsychiatric Diseases.Frontiers in neuroscience · 2020Review
- The adaptive brain in mental health: overcoming inherited risk factors.Journal of psychiatry & neuroscience : JPN · 2017Article
- DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Genome-Wide Epigenetic Characterization of Tissues from Three Germ Layers Isolated from Sheep Fetuses.Frontiers in genetics · 2017Article
- Attention-deficit/hyperactivity disorder associated with KChIP1 rs1541665 in Kv channels accessory proteins.PloS one · 2017Article
- Epigenetic Modifications of Major Depressive Disorder.International journal of molecular sciences · 2016Review
- Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function.Environmental epigenetics · 2016Review
- Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms.Nature communications · 2016Article
- Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins.Translational psychiatry · 2015Article
- Genome Wide Methylome Alterations in Lung Cancer.PloS one · 2015Article
- DNA methylation signatures link prenatal famine exposure to growth and metabolism.Nature communications · 2014Article
- Hypermethylation in the ZBTB20 gene is associated with major depressive disorder.Genome biology · 2014Article
- Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid.Epigenetics & chromatin · 2014Article
- Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.Frontiers in psychiatry · 2014Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Early life adversity, including adverse gestational and postpartum maternal environment, is a contributing factor in the development of autism, attention deficit hyperactivity disorder (ADHD), anxiety and depression but little is known about the underlying molecular mechanism. In a model of gestational maternal adversity that leads to innate anxiety, increased stress reactivity and impaired vocal communication in the offspring, we asked if a specific DNA methylation signature is associated with the emergence of the behavioral phenotype. Genome-wide DNA methylation analyses identified 2.3% of CpGs as differentially methylated (that is, differentially methylated sites, DMSs) by the adverse environment in ventral-hippocampal granule cells, neurons that can be linked to the anxiety phenotype. DMSs were typically clustered and these clusters were preferentially located at gene bodies. Although CpGs are typically either highly methylated or unmethylated, DMSs had an intermediate (20-80%) methylation level that may contribute to their sensitivity to environmental adversity. The adverse maternal environment resulted in either hyper or hypomethylation at DMSs. Clusters of DMSs were enriched in genes that encode cell adhesion molecules and neurotransmitter receptors; some of which were also downregulated, indicating multiple functional deficits at the synapse in adversity. Pharmacological and genetic evidence links many of these genes to anxiety.
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