Evidence map›Paper›PMID 23340244›Full record

ReviewNeuroscience2013

Translational developmental studies of stress on brain and behavior: implications for adolescent mental health and illness?

M Malter Cohen, N Tottenham, B J Casey

Abstract readReview
In one paragraph

Review in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Momentary effects of life stressors on mindfulness and emotion regulation difficulties among adolescents exposed to chronic stressors.Stress and health : journal of the International Society for the Investigation of Stress · 2024
    Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Communicating With and Supporting Youth Diagnosed With COVID-19: A Trauma-Informed Care Approach.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M Malter CohenSackler Institute for Developmental Psychobiology, Weill Cornell Medical College, 1300 York Avenue, P.O. Box 140, New York, NY 10065, USA. mhm2002@med.cornell.edu
N Tottenham
B J Casey

Funding

Role of conflict in memoryP50MH062196 · NIMH · PRINCETON UNIVERSITY · PI COHEN, JONATHAN D · 2000 to 2009
$18.9M
Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving AdversitiesR01MH091864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MILHAM, MICHAEL PETER, TOTTENHAM, NIM · 2010 to 2022
$5.1M
Development of Basic Components of Decision MakingR01DA018879 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASEY, BETTY J · 2004 to 2008
$2.0M
Brain Development Following InstitutionalizationR01MH073175 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASEY, BETTY J · 2004 to 2008
$2.0M
NIDA NIH HHS R01 DA018879NIMH NIH HHS 1R01 MH73175NIMH NIH HHS P50 MH062196NIMH NIH HHS P50 MH62196NIMH NIH HHS R01 MH073175NIMH NIH HHS R01 MH091864
6 · The paper itself

Abstract

Adolescence is the transition from childhood to adulthood, with onset marked by puberty and the offset by relative independence from parents. Across species, it is a time of incredible change that carries increased risks and rewards. The ability of the individual to respond adequately to the mental, physical and emotional stresses of life during this time is a function of both their early environment and their present state. In this article, we focus on the effects that acute threat and chronic stress have on the brain and behavior in humans and rodents. First, we highlight developmental changes in frontolimbic function as healthy individuals transition into and out of adolescence. Second, we examine genetic factors that may enhance susceptibility to stress in one individual over another using translation from genetic mouse models to human neuroimaging. Third, we examine how the timing and nature of stress varies in its impact on brain and behavior. These findings are discussed in the context of implications for adolescent mental health and illness.

Indexed as

Mental HealthAdolescentAdolescent BehaviorAnimalsBrainHumansMental DisordersStress, PsychologicalTranslational Research, BiomedicaladolescenceanxietyBDNFBDNFmetbrain-derived neurotrophic factoremotion regulationfearfMRIfunctional magnetic resonance imagingmagnetic resonance imagingMetmethioninemethionine in codon 66 of the BDNF proteinMRIPPIpostnatal daypreviously institutionalizedSCRskin conductance responsestressValVal66metvalinevaline-to-methionine substitution at codon 66ventromedial prefrontal cortexvmPFC

Identifiers

PMID23340244
PMCPMC3696429

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.