ArticleJournal of clinical hypertension (Greenwich, Conn.)2013
Patterns of nonadherence to antihypertensive therapy in primary care.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- The effect of pursed-lip breathing combined with number counting on blood pressure and heart rate in hypertensive urgency patients: A randomized controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2021Trial
- Characteristics, drug combinations and dosages of primary care patients with uncontrolled ambulatory blood pressure and high medication adherence.Journal of the American Society of Hypertension : JASHTrial
- Comparison of Pharmacy Refill Data With Chemical Adherence Testing in Assessing Medication Nonadherence in a Safety Net Hospital Setting.Journal of the American Heart Association · 2022Article
- Patient adherence to antihypertensive medications in upper Egypt: a cross-sectional study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2020Article
- Deception in clinical trials and its impact on recruitment and adherence of study participants.Contemporary clinical trials · 2018Review
- White-Coat Effect Is Uncommon in Patients With Refractory Hypertension.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Refractory and Resistant Hypertension: Antihypertensive Treatment Failure versus Treatment Resistance.Korean circulation journal · 2016Review
- Evaluating the impact of summer vacation on the visual acuity of AMD patients treated with ranibizumab.Eye (London, England) · 2015Article
- The evolving clinical management of hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nonadherence to medications is an important cause of poor blood pressure control. Long-acting antihypertensive agents could theoretically be beneficial in partially adherent patients, who are commonly seen in contemporary practice. Little has been reported about the duration of drug holidays (DHs) in treated hypertensives outside of generally compliant patients in phase 4 clinical trials. The authors described patterns of nonadherence to single and multiple antihypertensives in a random sample of 120 primary care patients with uncontrolled hypertension. Adherence to up to 3 antihypertensives was measured by electronic monitoring. Frequencies of single-day omissions and DHs of 2 consecutive days (DH2), 3 days (DH3), or ≥4 days (DH≥4) for each drug were calculated. Overall, 89 (74%) of patients had at least a 1-day omission. A single day omission was found in 61.4% of the patients taking 1 drug, followed by DH≥4 (28.1%), DH2 (26.3%), and DH3 (8.8%). In patients using multiple drugs, single-day omissions were also most common, followed by DH≥4, DH2, and DH3. Omissions of ≤3 days comprise on average 74% of all omissions. Although encouraging full adherence remains important, it may be prudent to prescribe long-acting antihypertensive agents, which can compensate for the majority of dose omissions.
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Registered trials
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