ReviewVirology journal2013
Strategies to develop antivirals against enterovirus 71.
Review in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Overview of the Trending Enteric Viruses and Their Pathogenesis in Intestinal Epithelial Cell Infection.Biomedicines · 2024Review
- In vitro synergistic antiviral activity of repurposed drugs against enterovirus 71.Archives of virology · 2024Article
- Isolation and Characterization of scFv Antibody against Internal Ribosomal Entry Site of Enterovirus A71.International journal of molecular sciences · 2023Article
- Efficient Strategy to Design Protease Inhibitors: Application to Enterovirus 71 2A Protease.ACS bio & med chem Au · 2022Article
- Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses.Acta pharmacologica Sinica · 2022Article
- Berberine prevents lethal EV71 neurological infection in newborn mice.Frontiers in pharmacology · 2022Article
- Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation.Journal of virology · 2019Article
- Inhibition of enterovirus 71 replication and viral 3C protease by quercetin.Virology journal · 2018Article
- Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization.The Kaohsiung journal of medical sciences · 2018Article
- Potential of small-molecule fungal metabolites in antiviral chemotherapy.Antiviral chemistry & chemotherapy · 2017Review
- Modelling person-to-person transmission in an Enterovirus A71 orally infected hamster model of hand-foot-and-mouth disease and encephalomyelitis.Emerging microbes & infections · 2017Article
- Glucocorticoids Prevent Enterovirus 71 Capsid Protein VP1 Induced Calreticulin Surface Exposure by Alleviating Neuronal ER Stress.Neurotoxicity research · 2017Article
- Enterovirus 71 infection and vaccines.Clinical and experimental vaccine research · 2017Review
- [Association of TLR3-1377C/T gene polymorphisms and expression with susceptibility to enterovirus 71 encephalitis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomolecules & therapeutics · 2016Article
- Anti-Enterovirus 71 Agents of Natural Products.Molecules (Basel, Switzerland) · 2015Review
- Yakammaoto inhibits enterovirus 71 infection by reducing viral attachment, internalization, replication, and translation.The Kaohsiung journal of medical sciences · 2015Article
- Synthesis and antiviral activity of a series of novel N-phenylbenzamide and N-phenylacetophenone compounds as anti-HCV and anti-EV71 agents.Acta pharmaceutica Sinica. B · 2015Article
- Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterovirus 71 (EV71) is an important human pathogen which may cause severe neurological complications and death in children. The virus caused several outbreaks in the Asia-Pacific region during the past two decades and has been considered a significant public health problem in the post-poliovirus eradication era. Unlike poliovirus, there is no effective vaccine or approved antivirals against EV71. To explore anti-EV71 agents therefore is of vital importance. Several strategies have been employed to develop antivirals based on the molecular characteristics of the virus. Among these, some small molecules that were developed against human rhinoviruses and poliovirus are under evaluation. In this review, we discuss the recent development of such small molecules against EV71, known drug resistance and possible solutions to it, and animal models for evaluating the efficacy of these antivirals. Although further investigation is required for clinical applications of the existing candidates, the molecular mechanisms revealed for the inhibition of EV71 replication can be used for designing new molecules against this virus in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.