ArticleParasites & vectors2013
Ability to cause erythema migrans differs between Borrelia burgdorferi sensu lato isolates.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
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- Ixodid ticks and zoonotic tick-borne pathogens of the Western Balkans.Parasites & vectors · 2024Review
- Lyme Disease in Humans.Current issues in molecular biology · 2021Article
- Lyme Disease Frontiers: ReconcilingPathogens (Basel, Switzerland) · 2019Review
- Chronic Lyme Disease: An Evidence-Based Definition by the ILADS Working Group.Antibiotics (Basel, Switzerland) · 2019Article
- Seroprevalence of vector-borne pathogens in dogs from Croatia.Parasitology research · 2019Article
- Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.International journal of general medicine · 2019Article
- Direct Molecular Detection and Genotyping of Borrelia burgdorferi Sensu Lato in Cerebrospinal Fluid of Children with Lyme Neuroborreliosis.Journal of clinical microbiology · 2018Article
- The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis.Frontiers in neurology · 2018Review
- Spotted fever group rickettsiae in ticks of migratory birds in Romania.Parasites & vectors · 2016Article
- Lyme neuroborreliosis-epidemiology, diagnosis and management.Nature reviews. Neurology · 2015Review
- Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis.Parasitology research · 2015Article
- Pilot study assessing the effectiveness of factory-treated, long-lasting permethrin-impregnated clothing for the prevention of tick bites during occupational tick exposure in highly infested military training areas, Germany.Parasitology research · 2015Article
- Identification of Borrelia species after creation of an in-house MALDI-TOF MS database.PloS one · 2014Article
- Tick-borne pathogen - reversed and conventional discovery of disease.Frontiers in public health · 2014Review
- Co-infection of Borrelia burgdorferi sensu lato and Rickettsia species in ticks and in an erythema migrans patient.Parasites & vectors · 2013Article
- Sensitivity of a point of care tick-test for the development of Lyme borreliosis.Parasites & vectors · 2013Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLyme borreliosis is a tick-borne disease caused by Borrelia burgdorferi sensu lato. The variety of characteristic and non-specific clinical manifestations is partially explained by its genetic diversity. We investigated the ability of B. burgdorferi sl isolates to cause erythema migrans.
methodsThe genetic constellation of isolates from ticks was compared to isolates found in erythema migrans. PCR and sequence analysis was performed on the plasmid-encoded ospC and the chromosomal 5S-23S rDNA spacer region (IGS).
resultsSeven different B. burgdorferi sl genospecies were identified in 152 borrelia isolates from ticks and erythema migrans biopsies. B afzelii (51%) and B. garinii (27%) were the most common in ticks. From the 44 sequences obtained from erythema migrans samples 42 were B. afzelii, one B. garinii and one B. bavariensis. Significant associations with erythema migrans formation were found for four IGS and two ospC types. Five from 45 ospC types were associated with more than one genospecies.
conclusionsB. burgdorferi sl isolates differ in their propensity to cause erythema migrans. These differences were also found within genospecies. In other words, although B. afzelii was mostly associated with erythema migrans, some B. afzelii isolates had a low ability to cause erythema migrans. Our data further support the occurrence of plasmid exchange between borrelia genospecies under natural conditions.
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