ReviewCritical reviews in biochemistry and molecular biology
Regulation of actin dynamics and protein trafficking during spermatogenesis--insights into a complex process.
Review in Critical reviews in biochemistry and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Actin Cytoskeleton Dysregulation Links Testicular and Sperm Dysfunction in Type 1 Diabetes.International journal of molecular sciences · 2026Article
- Article
- Blood-testis barrier: a review on regulators in maintaining cell junction integrity between Sertoli cells.Cell and tissue research · 2024Review
- Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression.Journal of molecular histology · 2023Article
- Article
- Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction.Clinical science (London, England : 1979) · 2022Article
- Proteome Informatics in Tibetan Sheep (Frontiers in veterinary science · 2022Article
- The Structure, Activity, and Function of the SETD3 Protein Histidine Methyltransferase.Life (Basel, Switzerland) · 2021Review
- Spermiation: Insights from Studies on the Adjudin Model.Advances in experimental medicine and biology · 2021Review
- Use of Molecular Modeling to Study Spermatogenesis: An Overview Using Proteins in Sertoli Cells.Advances in experimental medicine and biology · 2021Review
- Toxicological effects of bioactive peptide fractions obtained fromThe journal of venomous animals and toxins including tropical diseases · 2020Article
- Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking.Cellular and molecular life sciences : CMLS · 2020Article
- Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- mTORC1/rpS6 regulates blood-testis barrier dynamics and spermatogenetic function in the testis in vivo.American journal of physiology. Endocrinology and metabolism · 2018Article
- Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons.Methods in molecular biology (Clifton, N.J.) · 2018Review
- SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells.Oncotarget · 2017Article
- Drebrin and Spermatogenesis.Advances in experimental medicine and biology · 2017Article
- Planar cell polarity (PCP) proteins and spermatogenesis.Seminars in cell & developmental biology · 2016Review
- Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis.Endocrinology · 2016Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In the mammalian testis, extensive restructuring takes place across the seminiferous epithelium at the Sertoli-Sertoli and Sertoli-germ cell interface during the epithelial cycle of spermatogenesis, which is important to facilitate changes in the cell shape and morphology of developing germ cells. However, precise communications also take place at the cell junctions to coordinate the discrete events pertinent to spermatogenesis, namely spermatogonial renewal via mitosis, cell cycle progression and meiosis, spermiogenesis and spermiation. It is obvious that these cellular events are intimately related to the underlying actin-based cytoskeleton which is being used by different cell junctions for their attachment. However, little is known on the biology and regulation of this cytoskeleton, in particular its possible involvement in endocytic vesicle-mediated trafficking during spermatogenesis, which in turn affects cell adhesive function and communication at the cell-cell interface. Studies in other epithelia in recent years have shed insightful information on the intimate involvement of actin dynamics and protein trafficking in regulating cell adhesion and communications. The goal of this critical review is to provide an updated assessment of the latest findings in the field on how these complex processes are being regulated during spermatogenesis. We also provide a working model based on the latest findings in the field including our laboratory to provide our thoughts on an apparent complicated subject, which also serves as the framework for investigators in the field. It is obvious that this model will be rapidly updated when more data are available in future years.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.