ArticleRheumatology (Oxford, England)2013
The relationship between EQ-5D, HAQ and pain in patients with rheumatoid arthritis.
Article in Rheumatology (Oxford, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2021Pooled it
- Systematic Literature Review of Economic Evaluations of Biological Treatment Sequences for Patients with Moderate to Severe Rheumatoid Arthritis Previously Treated with Disease-Modifying Anti-rheumatic Drugs.PharmacoEconomics · 2020Pooled it
- Health State Preference Weights for the Glasgow Outcome Scale Following Traumatic Brain Injury: A Systematic Review and Mapping Study.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2017Pooled it
- Health economic modelling of treatment sequences for rheumatoid arthritis: a systematic review.Current rheumatology reports · 2014Pooled it
- Estimating pain visual analogue scale from health assessment questionnaire for rheumatoid arthritis with beta mixture models.Rheumatology international · 2025Trial
- Predicting EQ-5D-3L utility values from clinical data in a prospective cohort of kidney transplant recipients.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Observational
- Web-based models to inform health policy: A scoping review.Health research policy and systems · 2025Article
- Cost-effectiveness analysis of Tocilizumab compared to Adalimumab in the treatment of severe active rheumatoid arthritis in Iran.Cost effectiveness and resource allocation : C/E · 2024Article
- Observational
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Mapping the Patient-Reported Outcomes Measurement Information System (PROMIS-29) to EQ-5D-5L.PharmacoEconomics · 2023Article
- Mapping health assessment questionnaire disability index onto EQ-5D-5L in China.Frontiers in public health · 2023Article
- An examination of machine learning to map non-preference based patient reported outcome measures to health state utility values.Health economics · 2022Article
- Filgotinib for Moderate to Severe Rheumatoid Arthritis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.PharmacoEconomics · 2021Review
- Article
- The Effect of Dose Escalation on the Cost-Effectiveness of Etanercept and Adalimumab with Methotrexate Among Patients with Moderate to Severe Rheumatoid Arthritis.Journal of managed care & specialty pharmacy · 2020Article
- Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods.Health technology assessment (Winchester, England) · 2020Article
- Validity and reliability of EQ-5D-5L among patients with axial spondyloarthritis in Singapore.European journal of rheumatology · 2020Article
- A Flexible Open-Source Decision Model for Value Assessment of Biologic Treatment for Rheumatoid Arthritis.PharmacoEconomics · 2019Article
- Factors influencing physical activity in patients with early rheumatoid arthritis: A mixed-methods study.SAGE open medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to provide robust estimates of EQ-5D as a function of the HAQ and pain in patients with RA.
methodRepeated observations were made of patients diagnosed with RA in a US observational cohort (n = 100 398 observations) who provided data on HAQ, pain on a visual analogue scale and the EQ-5D questionnaire. We used a bespoke statistical method based on mixture modelling to appropriately reflect the characteristics of the EQ-5D instrument and to compare this with results from standard multiple regression.
resultsEQ-5D can be predicted from summary HAQ and pain scores. We identify four different classes of respondents who differ in terms of disease severity. Unlike the multiple regression, the mixture model exhibits very good fit to the data and does not suffer from problems of bias or predict values outside the feasible range.
conclusionIt is appropriate to model the relationship between HAQ and EQ-5D but only if suitable statistical methods are applied. Linear models underestimate the quality-adjusted life year benefits, and therefore the cost-effectiveness, of therapies. The bespoke mixture model approach outlined here overcomes this problem. The addition of pain as an explanatory variable greatly improves the estimates. Reimbursement agencies rely on these types of analyses when formulating policy on the use of new drug therapies. Clinicians as well as economists should be concerned with these issues.
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