ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2013
Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 5 of them syntheses that pooled it.
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66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- The dilemma of chronic kidney disease and end-stage kidney disease following pre-eclampsia: a literature review and meta-analysis.International urology and nephrology · 2025Pooled it
- A systematic review on the determinants of long-term kidney sequelae after hypertensive diseases of pregnancy.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Adverse Pregnancy Outcomes and Long-term Maternal Kidney Disease: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.Transplantation · 2017Guideline
- Hypertensive disorders during pregnancy and risk of type 2 diabetes in later life: a systematic review and meta-analysis.Endocrine · 2017Pooled it
- Effects of prenatal micronutrients supplementation timing on pregnancy-induced hypertension: Secondary analysis of a double-blind randomized controlled trial.Maternal & child nutrition · 2021Trial
- Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial.Clinical nutrition (Edinburgh, Scotland) · 2019Trial
- Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study.Disease markers · 2016Trial
- Divergent Risk Factors and Outcomes in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome and Isolated Preeclampsia.Kidney international reports · 2026Article
- Laboratory Signs of CKD after Preeclampsia.Journal of the American Society of Nephrology : JASN · 2026Article
- Subclinical Postpartum Renal Structure After Hypertensive Pregnancy Disorders.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Prevalence and correlates of hypertension among women of reproductive age in Tanzania: a nationwide cross-sectional study.BMJ public health · 2025Article
- Hypertension and associated complications in pregnant women with chronic kidney disease.World journal of nephrology · 2024Review
- Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy.Comprehensive Physiology · 2024Review
- Pregnancy-Induced Hypertension Pathophysiology and Contemporary Management Strategies: A Narrative Review.Cureus · 2024Review
- Trophoblast Differentiation: Mechanisms and Implications for Pregnancy Complications.Nutrients · 2023Review
- The effect of thromboembolic prophylaxis after cesarean section in patients with hypertensive disorders.Northern clinics of Istanbul · 2023Article
- The Hypertensive Disorders of Pregnancy: A Focus on Definitions for Clinical Nephrologists.Journal of clinical medicine · 2022Review
- Long-term observational study of renal outcome after preeclampsia: Role of soluble fms-like tyrosine kinase-1(sFlt-1)/ placental growth factor (PlGF) and endoglin.Annals of medicine and surgery (2012) · 2022Article
- Hypertensive Disorders of Pregnancy With and Without Prepregnancy Hypertension Are Associated With Incident Maternal Kidney Disease Subsequent to Delivery.Hypertension (Dallas, Tex. : 1979) · 2022Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies into the association between hypertensive disorders during pregnancy and end-stage renal disease are limited. We investigated the risk of end-stage renal disease after delivery among women with hypertensive disorders during pregnancy.
methodsWe used insurance claims data from 1998 to 2009 to identify 26,651 women aged 19-40 years old who experienced hypertensive disorders during pregnancy; these women had no history of hypertension, diabetes, kidney disease or lupus. We also randomly selected 213,397 women without hypertensive disorders during pregnancy as a comparison cohort; the frequency was matched by age and index year of pregnancy. We compared the incidence of end-stage renal disease in the 2 cohorts. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) after controlling for demographic and clinical factors.
resultsWomen with hypertensive disorders during pregnancy had a greater risk of chronic kidney disease and end-stage renal disease, with adjusted HRs of 9.38 (95% CI 7.09-12.4) and 12.4 (95% CI 8.54-18.0), respectively, after controlling for urban status, coronary artery disease, congestive heart failure, hyperlipidemia and abruption. The HR for end-stage renal disease was 2.72 (95% CI 1.76-4.22) after we also controlled for hypertension and diabetes. Women with preeclampsia or eclampsia had a higher risk of end-stage renal disease (adjusted HR 14.0, 95% CI 9.43-20.7) than women who had gestational hypertension only (adjusted HR 9.03, 95% CI 5.20-15.7).
interpretationWomen with hypertensive disorders during pregnancy were at a high risk of end-stage renal disease. The risk was much greater for women who had preeclampsia or eclampsia than those who had gestational hypertension only.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.