Evidence map›Paper›PMID 23338987›Full record

ReviewSports medicine (Auckland, N.Z.)2013

Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training.

Brad J Schoenfeld

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 171 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 13 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07213726 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Quantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System

TypeinterventionalSponsorAndrews Research & Education FoundationRan2022 to 2026Enrolled15ConditionsBlood Flow Restriction (BFR) Training EffectsArmsDelfi Personalized Tourniquet System
NCT07538037 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Low-Intensity Blood Flow Restriction Training on Lower-Limb Strength and Kicking Performance in Taekwondo Athletes: A Randomized Controlled Trial

TypeinterventionalSponsorShanghai University of SportRan2026 to 2026Enrolled18ConditionsPhysical Performance, Athletic PerformanceArmsLI-BFRT, HIRT
3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 13 syntheses or guidelines pooled it, 481 citations in OpenAlex.

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  12. Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Brad J SchoenfeldDepartment of Health Sciences, Program of Exercise Science, APEX Building, Room # 265, Lehman College, CUNY, 250 Bedford Park Blvd West, Bronx, NY 10468, USA. brad@workout911.com
Lehman College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well established that regimented resistance training can promote increases in muscle hypertrophy. The prevailing body of research indicates that mechanical stress is the primary impetus for this adaptive response and studies show that mechanical stress alone can initiate anabolic signalling. Given the dominant role of mechanical stress in muscle growth, the question arises as to whether other factors may enhance the post-exercise hypertrophic response. Several researchers have proposed that exercise-induced metabolic stress may in fact confer such an anabolic effect and some have even suggested that metabolite accumulation may be more important than high force development in optimizing muscle growth. Metabolic stress pursuant to traditional resistance training manifests as a result of exercise that relies on anaerobic glycolysis for adenosine triphosphate production. This, in turn, causes the subsequent accumulation of metabolites, particularly lactate and H(+). Acute muscle hypoxia associated with such training methods may further heighten metabolic buildup. Therefore, the purpose of this paper will be to review the emerging body of research suggesting a role for exercise-induced metabolic stress in maximizing muscle development and present insights as to the potential mechanisms by which these hypertrophic adaptations may occur. These mechanisms include increased fibre recruitment, elevated systemic hormonal production, alterations in local myokines, heightened production of reactive oxygen species and cell swelling. Recommendations are provided for potential areas of future research on the subject.

Indexed as

Adaptation, PhysiologicalResistance TrainingStress, PhysiologicalHormonesHumansHypertrophyMuscle, SkeletalHormones

Identifiers

PMID23338987
OpenAlexW2034772408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.