Evidence map›Paper›PMID 23338283›Full record

ReviewNature reviews. Neurology2013

Eye movements in patients with neurodegenerative disorders.

Tim J Anderson, Michael R MacAskill

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05437003 (A Cross-Sectional Study to Evaluate the Correlation Between Oculometric Measures and MDS-UPDRS in Patients With Idiopathic Parkinson's Disease), which is not on this map. Cited by 162 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 5 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05437003 nacompletednot on this mapstarted 2022, after this paper: background citation

A Cross-Sectional Study to Evaluate the Correlation Between Oculometric Measures and MDS-UPDRS in Patients With Idiopathic Parkinson's Disease (PD) and Evaluation of Oculometric Measures in Healthy Participants

TypeinterventionalSponsorNeuraLightRan2022 to 2024Enrolled465ConditionsIdiopathic Parkinson DiseaseArmsNeuraLight software-based platform
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 5 syntheses or guidelines pooled it, 355 citations in OpenAlex.

  1. Pooled it
  2. Ocular microtremor: a structured review.Experimental brain research · 2023
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  19. Combining Cognitive and Sensorimotor Assessments to Facilitate Detection of Age-Related Cognitive Decline.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tim J AndersonDepartment of Medicine, University of Otago Christchurch, 2 Riccarton Avenue, Christchurch 8011, New Zealand. tim.anderson@ otago.ac.nz
Michael R MacAskill
New Zealand Brain Research Institute · NZUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural pathways and brain regions involved in eye movements during ocular fixation and gaze control include the cerebrum, brainstem and cerebellum, and abnormal eye movements can indicate the presence of neurodegeneration. In some patients, oculomotor signs are key to making a diagnosis. Careful clinical examination of eye movements in patients with neurodegenerative disorders is, therefore, an invaluable adjunct to neurological and cognitive assessments. Eye movement recordings in the laboratory are generally not necessary for diagnostic purposes, but can be a useful addition to the clinical examination. Laboratory recordings of eye movements can provide valuable information about disease severity, progression or regression in neurodegenerative disease, and hold particular promise for objective evaluation of the efficacy of putative neuroprotective and neurorestorative therapies. For example, aspects of saccade performance can be tested to probe both motor and cognitive aspects of oculomotor behaviour. This Review describes the oculomotor features of the major age-related movement disorders, including Parkinson disease, Huntington disease, dementia and other neurodegenerative disorders. Findings in presymptomatic individuals and changes associated with disease progression are discussed.

Indexed as

Basal Ganglia DiseasesBiomarkersDementiaEye MovementsHumansHuntington DiseaseLewy Body DiseaseMultiple System AtrophyNeurodegenerative DiseasesParkinsonian DisordersPsychomotor PerformanceSupranuclear Palsy, ProgressiveBiomarkers

Identifiers

PMID23338283
OpenAlexW2092491661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.