ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Lack of association between COMT and working memory in a population-based cohort of healthy young adults.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study.Drug and alcohol dependence · 2013Trial
- Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa.PloS one · 2013Trial
- The therapeutic potential of COMT inhibition: cognition and beyond.Molecular psychiatry · 2026Review
- Article
- Gradual Loss of Social Group Support during Competition Activates Anterior TPJ and Insula but Deactivates Default Mode Network.Brain sciences · 2023Article
- Influence of COMT polymorphism in cognitive performance on dementia in community-dwelling elderly Mexican (SADEM study).Metabolic brain disease · 2021Article
- Childhood Trauma, the Combination of MAO-A and COMT Genetic Polymorphisms and the Joy of Being Aggressive in Forensic Psychiatric Patients.Brain sciences · 2021Article
- First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Interaction of Catechol-O-methyltransferase ValBrain and behavior · 2020Article
- Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View.Frontiers in pediatrics · 2020Article
- Brain-based Classification of Negative Social Bias in Adolescents With Nonsuicidal Self-injury: Findings From Simulated Online Social Interaction.EClinicalMedicine · 2019Article
- Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes.Alcoholism, clinical and experimental research · 2019Article
- Article
- Alcohol Use in Adolescence and Later Working Memory: Findings From a Large Population-Based Birth Cohort.Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Article
- Cognitive Effects of Nicotine: Recent Progress.Current neuropharmacology · 2018Review
- Right Forceps Minor and Anterior Thalamic Radiation Predict Executive Function Skills in Young Bilingual Adults.Frontiers in psychology · 2018Article
- Sex-specific effects ofBrain and behavior · 2017Article
- Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease.Experimental and therapeutic medicine · 2016Article
- Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype.Psychopharmacology · 2016Article
- Genetic Moderation of Stress Effects on Corticolimbic Circuitry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is an important regulator of dopamine in the prefrontal cortex, an area critical to working memory. Working memory deficits are present in several psychiatric disorders, and there is wide variation in working memory capacity in the normal population. Association studies of COMT and working memory in healthy volunteers have yielded inconsistent results, possibly because of small sample sizes. Here we examine COMT in relation to N-Back working memory task performance in a large population-based cohort of young adults. We predicted individuals with one or two copies of the Met allele would perform better, and that this relationship would be more evident in males than females. Participants (N=1857-2659) tested at 18 years of age, were enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). We used multiple regression to examine effects of sex and COMT genotype on N-Back hits, false positives, discriminability (d'), and reaction time while controlling for important covariates. COMT genotype did not predict hits or d'. There was a nominally significant interaction between COMT and sex on false positives, but this was not in the predicted direction, and was not significant after controlling for covariates. COMT genotype was not related to working memory in this large population-based cohort. It is possible COMT is not meaningfully associated with working memory in healthy young adults, or that COMT effects are detectable only in assessments reflecting neural processes underlying cognition, such as fMRI, rather than in behavioral performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.