ArticleEMBO reports2013
Brk regulates wing disc growth in part via repression of Myc expression.
Article in EMBO reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Genomics of a sexually selected sperm ornament and female preference in Drosophila.Nature ecology & evolution · 2025Article
- Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors.Development (Cambridge, England) · 2023Article
- Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism.Nature communications · 2021Article
- Anchor Away - A Fast, Reliable and Reversible Technique To Inhibit Proteins inG3 (Bethesda, Md.) · 2020Article
- The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway inBiology open · 2020Article
- Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action.eLife · 2017Article
- Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling.Genes · 2017Review
- The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184.Journal of cell science · 2016Article
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- The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region.PLoS genetics · 2015Article
- Conservation of transcription factor binding specificities across 600 million years of bilateria evolution.eLife · 2015Article
- Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila.Genetics · 2014Article
- Socializing with MYC: cell competition in development and as a model for premalignant cancer.Cold Spring Harbor perspectives in medicine · 2014Review
- Myc function in Drosophila.Cold Spring Harbor perspectives in medicine · 2013Review
- Developmental roles of Drosophila tRNA processing endonuclease RNase ZL as revealed with a conditional rescue system.Developmental biology · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The molecular mechanisms regulating tissue size represent an unsolved puzzle in developmental biology. One signalling pathway controlling growth of the Drosophila wing is Dpp. Dpp promotes growth by repression of the transcription factor Brk. The transcriptional targets of Brk that control cell growth and proliferation, however, are not yet fully elucidated. We report here a genome-wide ChIP-Seq of endogenous Brk from wing imaginal discs. We identify the growth regulator Myc as a target of Brk and show that repression of Myc and of the miRNA bantam explains a significant fraction of the growth inhibition caused by Brk. This work sheds light on the effector mechanisms by which Dpp signalling controls tissue growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.