Evidence map›Paper›PMID 23337534›Full record

ReviewNeuroscience2013

Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function.

J L Knauss, T Sun

Abstract readReview
In one paragraph

Review in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
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  12. Transcriptomic Analysis ofInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis.Cancer biomarkers : section A of Disease markers · 2023
    Article
  15. Article
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  17. Article
  18. Article
  19. Article
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J L KnaussDepartment of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY, United States. jlk2006@med.cornell.edu
T Sun
Cornell University · US

Funding

MicroRNA Function in the Development of the Cerebral CortexR01MH083680 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA, STUHLMANN, HEIDI · 2009 to 2018
$4.2M
Training Program in Developmental BiologyT32HD060600 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BAO, ZHIRONG, STUHLMANN, HEIDI · 2010 to 2024
$3.5M
NICHD NIH HHS T32 HD060600NIMH NIH HHS R01 MH083680NIMH NIH HHS R01-MH083680
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) have emerged as an important class of molecules that regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels through a wide array of mechanisms. This regulation is of particular importance in the central nervous system (CNS), where precise modulation of gene expression is required for proper neuronal and glial production, connection and function. There are relatively few functional studies that characterize lncRNA mechanisms, but possible functions can often be inferred based on existing examples and the lncRNA's relative genomic position. In this review, we will discuss mechanisms of lncRNAs as predicted by genomic contexts and the possible impact on CNS development, function, and disease pathogenesis. There is no doubt that investigation of the mechanistic role of lncRNAs will open a new and exciting direction in studying CNS development and function.

Indexed as

AnimalsCentral Nervous SystemGenomicsHumansNervous System DiseasesNeurogliaNeuronsRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID23337534
PMCPMC3595319
OpenAlexW2019122937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.