ArticleThe American journal of gastroenterology2013
Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis.
Article in The American journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Does Combined Medical and Surgical Treatment Improve Perianal Fistula Outcomes in Patients With Crohn's Disease? A Systematic Review and Meta-Analysis.Journal of Crohn's & colitis · 2024Pooled it
- Depression after stoma surgery: a systematic review and meta-analysis.BMC psychiatry · 2023Pooled it
- Prevalence of depression and its potential contributing factors in patients with enterostomy: A meta-analytical review.Frontiers in psychiatry · 2022Pooled it
- Predicting the development of psychological morbidity in inflammatory bowel disease: a systematic review.Frontline gastroenterology · 2021Pooled it
- Psychiatric morbidity after surgery for inflammatory bowel disease: A systematic review.World journal of gastroenterology · 2017Pooled it
- ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease.The American journal of gastroenterology · 2017Guideline
- Effects of Intravenous Analgesia Using Tramadol on Postoperative Depression State and Sleep Quality in Women Undergoing Abdominal Endoscopic Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2022Trial
- Prevalence of symptoms of anxiety and depression in postoperative patients with Crohn's disease: a comparative cross-sectional study.BMC gastroenterology · 2026Article
- Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort.Alimentary pharmacology & therapeutics · 2025Article
- Associations with sexual dysfunction among a Canadian cohort with inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025Article
- Understanding the Perspectives and Experiences of Patients with Acute Severe Ulcerative Colitis in the Hospital: A Qualitative Analysis.Digestive diseases and sciences · 2024Article
- Prevalence and risk factors of depression among patients with perianal fistulizing Crohn's disease.World journal of psychiatry · 2024Article
- Depressive and Anxiety Disorders in Patients with Inflammatory Bowel Diseases: Are There Any Gender Differences?International journal of environmental research and public health · 2023Review
- Clinical Predictors of Depression among Patients with Inflammatory Bowel Diseases: A Cross-sectional Analytical Study from Oman.Oman medical journal · 2022Article
- Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis.International journal of colorectal disease · 2022Article
- Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice.Frontiers in immunology · 2022Review
- Glucocorticoid induced group 2 innate lymphoid cell overactivation exacerbates experimental colitis.Frontiers in immunology · 2022Article
- Reversal of end-ileostomy in patients with Crohn's disease.International journal of colorectal disease · 2021Article
- The evolution of IBD perceived engagement and care needs across the life-cycle: a scoping review.BMC gastroenterology · 2021Article
- Assessment of Comorbid Depression and Anxiety in Inflammatory Bowel Disease Using Adaptive Testing Technology.Crohn's & colitis 360 · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesPsychiatric comorbidity is common in Crohn's disease (CD) and ulcerative colitis (UC). Inflammatory bowel disease (IBD)-related surgery or hospitalizations represent major events in the natural history of the disease. The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC.
methodsWe used a multi-institution cohort of IBD patients without a diagnosis code for anxiety or depression preceding their IBD-related surgery or hospitalization. Demographic-, disease-, and treatment-related variables were retrieved. Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety.
resultsOur study included a total of 707 CD and 530 UC patients who underwent bowel resection surgery and did not have depression before surgery. The risk of depression 5 years after surgery was 16% and 11% in CD and UC patients, respectively. We found no difference in the risk of depression following surgery in the CD and UC patients (adjusted odds ratio, 1.11; 95% confidence interval, 0.84-1.47). Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. Only 12% of the CD cohort had ≥4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression.
conclusionsIBD-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.