ArticleValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Mapping from disease-specific to generic health-related quality-of-life scales: a common factor model.
Article in Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparability of Randomized Controlled Trials Evaluating Pharmacological Interventions for Pemphigus Vulgaris and Pemphigus Foliaceus: A Systematic Mapping Review.Advances in therapy · 2025Pooled it
- Quality of life in patients with HBV infection: A systematic review and meta-analysis.JHEP reports : innovation in hepatology · 2025Article
- Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study.The World Allergy Organization journal · 2024Article
- The German linguistic validation of the Wisconsin Stone Quality of Life questionnaire (WisQoL).World journal of urology · 2021Article
- Uptake of methodological advances for synthesis of continuous and time-to-event outcomes would maximize use of the evidence base.Journal of clinical epidemiology · 2020Review
- Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods.Health technology assessment (Winchester, England) · 2020Article
- Statistical Alchemy: Conceptual Validity and Mapping to Generate Health State Utility Values.PharmacoEconomics - open · 2017Article
- Mapping the EORTC QLQ-C30 onto the EQ-5D-3L: assessing the external validity of existing mapping algorithms.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Simultaneous synthesis of treatment effects and mapping to a common scale: an alternative to standardisation.Research synthesis methods · 2015Article
- Exploring the relationship between EQ-5D, DLQI and PASI, and mapping EQ-5D utilities: a cross-sectional study in psoriasis from Hungary.The European journal of health economics : HEPAC : health economics in prevention and care · 2014Article
- Simultaneous multioutcome synthesis and mapping of treatment effects to a common scale.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2014Article
- Should linking replace regression when mapping from profile-based measures to preference-based measures?Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2014Article
- Review of studies mapping from quality of life or clinical measures to EQ-5D: an online database.Health and quality of life outcomes · 2013Review
- Some comments on mapping from disease-specific to generic health-related quality-of-life scales.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes ResearchArticle
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3 authors.
Funding
Abstract
objectivesTo develop a coherent method for estimating mappings between treatment effects on disease-specific measurement (DSM) instruments and generic health-related quality-of-life (QOL) measures, when both are subject to measurement errors.
methodsWe identified three properties that must be satisfied for mappings to be logically coherent: invertability, transitivity, and invariance to linear transformation. Of the common regressions, ordinary least squares (OLS), geometric mean (GM), and orthogonal regression, only GM has all these properties, and then only in special cases. We developed a common factor model of how DSM and generic QOL scales are related, and derived expressions for coherent mapping coefficients. We showed that these are equivalent to adjusted forms of OLS or GM regressions. Where cohort data are available on just one DSM and one QOL measure, external data on the reproducibility of the DSM are required. In some circumstances, the mappings can be estimated without external data. We illustrated the estimation of mapping coefficients by using data on EuroQol five-dimensional (EQ-5D) questionnaire, 12-item short form health survey (SF-12) Mental Component Summary, and the Beck Depression Inventory (BDI), from a trial of treatments for depression.
resultsOLS underestimates and GM overestimates mappings from DSMs to generic QOL measures. Mappings estimated by using external data on reliability were similar to those estimated by using internal data, suggesting approximate adequacy of the common factor model.
conclusionsNeither OLS nor GM regression, unless corrected, is suitable for estimating mappings between disease-specific and generic QOL scales. OLS systematically underestimates mappings, but it can be adjusted by using external information on test-retest reliability.
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Registered trials
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