ArticleInfluenza and other respiratory viruses2013
Oxygen free radical involvement in acute lung injury induced by H5N1 virus in mice.
Article in Influenza and other respiratory viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 25 citations in OpenAlex.
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- Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection.Free radical biology & medicine · 2021Article
- Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury.Frontiers in immunology · 2021Review
- Redox control in the pathophysiology of influenza virus infection.BMC microbiology · 2020Review
- Modeling the oxidative consumption of curcumin from controlled released poly(beta-amino ester) microparticles in the presence of a free radical generating system.Regenerative biomaterials · 2019Article
- Anti-Inflammatory and Anti-Oxidant Activity ofMolecules (Basel, Switzerland) · 2019Article
- Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways.Molecules (Basel, Switzerland) · 2017Article
- iTRAQ-based quantitative proteomics reveals important host factors involved in the high pathogenicity of the H5N1 avian influenza virus in mice.Medical microbiology and immunology · 2017Article
- PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice.Medical microbiology and immunology · 2016Article
- Erythropoietin Pretreatment Attenuates Seawater Aspiration-Induced Acute Lung Injury in Rats.Inflammation · 2016Article
- NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-Mediators of inflammation · 2016Article
- Carnosine markedly ameliorates H9N2 swine influenza virus-induced acute lung injury.The Journal of general virology · 2015Article
- N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury.International immunopharmacology · 2014Article
- Intracellular redox state as target for anti-influenza therapy: are antioxidants always effective?Current topics in medicinal chemistry · 2014Review
- Oxygen free radical involvement in acute lung injury induced by H5N1 virus in mice.Influenza and other respiratory viruses · 2013Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute lung injury is an important cause of death in humans infected with H5N1. It has been found that oxygen free radicals (OFRs) are elevated in lung tissue during influenza virus infections. In this study, we used a mouse model to explore the role of OFRs in acute lung injury caused by H5N1 viral infection.
methodsFour- to six-week-old male specific pathogen-free BALB/c mice were inoculated intranasally with 10(5) 50% tissue culture infective doses (TCID50) of highly pathogenic A/Chicken/Hebei/108/2002 (H5N1) viruses and were then given 1000 IU of lauric acid modified superoxide dismutase (LA-SOD) by intraperitoneal injection, starting 2 days post-infection and continuing for 6 days.
resultsThe extent of lung injury and the concentration of OFRs were higher, and the SOD activity was lower in H5N1 virus-infected mice than that in uninfected control mice on days 3, 6, and 7 post-inoculation. Weak amelioration of clinical signs, a minor decrease in the total mortality and the extent of lung injury, and the lower OFRs concentration were seen in the LA-SOD treatment group, but a reduction in lung virus titers was not observed in the LA-SOD treatment at all time points.
conclusionsThe LA-SOD treatment has a mild inhibitory effect on H5N1 influenza virus infection in mice. OFRs, therefore, might play an important role in the pathogenesis of acute lung injury induced by H5N1 virus.
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