ArticleDiagnostic pathology2013
An alternative high output tissue microarray technique.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- FGFR3 amplification is predictive of poor prognosis in esophageal squamous cell carcinoma patients.Virchows Archiv : an international journal of pathology · 2025Article
- Evaluating CSPG4 expression in esophageal basaloid squamous cell carcinoma and conventional squamous cell carcinoma: a multi-institutional retrospective study in China.Virchows Archiv : an international journal of pathology · 2025Article
- IKZF3 amplification predicts worse prognosis especially in intestinal-type gastric cancer.Journal of cancer research and clinical oncology · 2024Article
- Somatostatin receptor subtype 2A expression and genetics in 184 paragangliomas: a single center retrospective observational study.Endocrine · 2024Observational
- Abnormal p16 expression and prognostic significance in esophageal squamous cell carcinoma.Histology and histopathology · 2024Article
- Optimization of tissue microarray technique for breast cancer patients: a short communication.Annals of medicine and surgery (2012) · 2023Article
- TMA-Mate: An open-source modular toolkit for constructing tissue microarrays of arbitrary layouts.HardwareX · 2023Article
- A Simplified Method of Manually Constructing Small Format Tissue Microarray for Use in Resource-Constrained Settings.Iranian journal of pathology · 2023Article
- Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues.Nature communications · 2022Article
- PMS2 Expression With Combination of PD-L1 and TILs for Predicting Survival of Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Prognostic value and characterization of NTRK1 variation by fluorescence in situ hybridization in esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2021Article
- Simple method for constructing and repairing tissue microarrays using simple equipment.The Journal of international medical research · 2021Article
- Article
- CDK4 Amplification in Esophageal Squamous Cell Carcinoma Associated With Better Patient Outcome.Frontiers in genetics · 2021Article
- HER2 Positivity Is Affected by the Papillary Structure and Has a Bidirectional Prognostic Value for Gallbladder Carcinoma.Frontiers in genetics · 2021Article
- The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer.Japanese journal of clinical oncology · 2020Article
- Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients.BMC cancer · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue microarray (TMA) is a high throughput research tool, which has greatly facilitated and accelerated in situ tissue analyses. However, its productivity has been restricted due to the confined thickness of traditional donor block. Here, we introduce an improved high output TMA method that is applicable to a broader range of tissue samples.
methodsIn this method, a 3.6 cm long and 2.7 cm wide recipient block with 88 square lattices (3 mm in width) was first prepared using several commercial instruments. A 2 mm wide and 6 mm long tissue rod was then prepared using a self-made blade-shaped knife from each paraffin embedded donor block of gastrointestinal stromal tumors. These rods were manually arrayed one by one into the corresponding lattices of the 60°C pre-softened recipient block with the guide of holes drilled with a steel needle. A 70-rod TMA was made to testify this method.
resultsThe prepared TMA had well defined array configurations, good tissue morphology and fully preserved proteins and DNA. A total of 500-1000 TMA sections could be easily obtained from a TMA block.
conclusionThis low-cost and time-saving method provides an alternative sampling tool for high output TMA. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1979605867857990.
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