ArticleBiology open2013
MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila.
Article in Biology open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Myc-regulated miRNAs modulate p53 expression and impact animal survival under nutrient deprivation.PLoS genetics · 2023Article
- Negative regulation of diminutive cancer regulator through differentiation and microRNA pathway components in Drosophila cells.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 inDevelopment (Cambridge, England) · 2020Article
- Review
- Identification of active miRNA promoters from nuclear run-on RNA sequencing.Nucleic acids research · 2017Article
- Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes.PLoS neglected tropical diseases · 2017Article
- Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling.Genes · 2017Review
- Targeting RNA polymerase I to treat MYC-driven cancer.Oncogene · 2015Review
- An intronic microRNA links Rb/E2F and EGFR signaling.PLoS genetics · 2014Article
- Wolbachia infection modifies the profile, shuttling and structure of microRNAs in a mosquito cell line.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The abundance of Myc protein must be exquisitely controlled to avoid growth abnormalities caused by too much or too little Myc. An intriguing mode of regulation exists in which Myc protein itself leads to reduction in its abundance. We show here that dMyc binds to the miR-308 locus and increases its expression. Using our gain-of-function approach, we show that an increase in miR-308 causes a destabilization of dMyc mRNA and reduced dMyc protein levels. In vivo knockdown of miR-308 confirmed the regulation of dMyc levels in embryos. This regulatory loop is crucial for maintaining appropriate dMyc levels and normal development. Perturbation of the loop, either by elevated miR-308 or elevated dMyc, caused lethality. Combining elevated levels of both, therefore restoring balance between miR-308 and dMyc levels, resulted in lower apoptotic activity and suppression of lethality. These results reveal a sensitive feedback mechanism that is crucial to prevent the pathologies caused by abnormal levels of dMyc.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.