Evidence map›Paper›PMID 23336046›Full record

ReviewACS chemical neuroscience2013

Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior.

Stefanie C Altieri, Alvaro L Garcia-Garcia, E David Leonardo, Anne M Andrews

Abstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Role of the Serotonergic System in Time Perception: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Pharmacologic MRI Brain Imaging Studies of Serotonin 5-HTPharmacology research & perspectives · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Serotonergic Regulation in Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. GMolecular pharmacology · 2023
    Article
  14. Article
  15. Review
  16. Review
  17. On Associations between Fear-Induced Aggression,International journal of molecular sciences · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stefanie C AltieriSemel Institute for Neuroscience & Human Behavior, Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States.
Alvaro L Garcia-Garcia
E David Leonardo
Anne M Andrews

Funding

A Late Sensitive Period for the Development of Anxiety DisordersR01MH091427 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LEONARDO, EDUARDO DAVID · 2010 to 2014
$2.0M
NIMH NIH HHS R01 MH091427
6 · The paper itself

Abstract

The complexities of the involvement of the serotonin transmitter system in numerous biological processes and psychiatric disorders is, to a substantial degree, attributable to the large number of serotonin receptor families and subtypes that have been identified and characterized for over four decades. Of these, the 5-HT(1A) receptor subtype, which was the first to be cloned and characterized, has received considerable attention based on its purported role in the etiology and treatment of mood and anxiety disorders. 5-HT(1A) receptors function both at presynaptic (autoreceptor) and postsynaptic (heteroreceptor) sites. Recent research has implicated distinct roles for these two populations of receptors in mediating emotion-related behavior. New concepts as to how 5-HT(1A) receptors function to control serotonergic tone throughout life were highlights of the proceedings of the 2012 Serotonin Club Meeting in Montpellier, France. Here, we review recent findings and current perspectives on functional aspects of 5-HT(1A) auto- and heteroreceptors with particular regard to their involvement in altered anxiety and mood states.

Indexed as

AffectAnimalsAntidepressive AgentsAnxiety DisordersAutoreceptorsDisease Models, AnimalFeedback, PhysiologicalForecastingHuman DevelopmentHumansMiceMice, KnockoutPrefrontal CortexReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AntagonistsSignal TransductionAntidepressive AgentsAutoreceptorsReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor Antagonists

Identifiers

PMID23336046
PMCPMC3547474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.