ArticleCommunicative & integrative biology2012
Mechano-sensing by actin filaments and focal adhesion proteins.
Article in Communicative & integrative biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells.Investigative ophthalmology & visual science · 2025Article
- Melt electrowritten poly-lactic acid /nanodiamond scaffolds towards wound-healing patches.Materials today. Bio · 2024Article
- Crowding alters F-actin secondary structure and hydration.Communications biology · 2023Article
- Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma.Journal of translational medicine · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Regulation of cell attachment, spreading, and migration by hydrogel substrates with independently tunable mesh size.Acta biomaterialia · 2022Article
- Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells.Acta biomaterialia · 2021Article
- Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells.PloS one · 2021Article
- Decoupling the effects of nanopore size and surface roughness on the attachment, spreading and differentiation of bone marrow-derived stem cells.Biomaterials · 2020Article
- Simultaneous Quantification of the Interplay Between Molecular Turnover and Cell Mechanics by AFM-FRAP.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Myosin-dependent actin stabilization as revealed by single-molecule imaging of actin turnover.Molecular biology of the cell · 2018Article
- Axonal Transport, Phase-Separated Compartments, and Neuron Mechanics - A New Approach to Investigate Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2018Review
- Mechanical heterogeneity favors fragmentation of strained actin filaments.Biophysical journal · 2015Article
- Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells.PloS one · 2015Article
- Mechanosensitive channels: feeling tension in a world under pressure.Frontiers in plant science · 2014Review
- Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Human plasma fibronectin promotes proliferation and differentiation of odontoblast.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanosensitive ion channels have long been the only established molecular class of cell mechanosensors with known molecular entities. However, recent advances in the state-of-the-art techniques, including single-molecule manipulation and imaging, have enabled an investigation of non-channel type cell mechanosensors and the underlying biophysical mechanisms of their activation. To date, two focal adhesion proteins, talin and p130Cas, have been postulated to act as putative mechanosensors, acting through mechano-induced unfolding of their particular soft domain(s) susceptible to phosphorylation. More recently, the actin filament has been demonstrated to act as a mechanosensor in the presence of the soluble actin-severing protein, cofilin. The cofilin severing activity negatively depends on the tension in the actin filament through tension-dependent binding/unbinding of cofilin to/from the actin filament. As a result, relaxed actin filaments are severed, while tensed ones are either not severed or severed after a long delay. Here we review the latest progress in the mechanosensing by non-channel type proteins and discuss the possible physiological roles of the mechanosensing performed by actin filaments in the course of cell migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.