ArticlePloS one2013
Genetic variation in plant CYP51s confers resistance against voriconazole, a novel inhibitor of brassinosteroid-dependent sterol biosynthesis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Sterols in plant biologyCell surface (Amsterdam, Netherlands) · 2025Review
- Transcriptomic analysis of cytochrome P450 genes and pathways involved in chromium toxicity in Oryza sativa.Ecotoxicology (London, England) · 2020Article
- Comprehensive Overview of the Brassinosteroid Biosynthesis Pathways: Substrates, Products, Inhibitors, and Connections.Frontiers in plant science · 2020Review
- Inhibitors of Brassinosteroid Biosynthesis and Signal Transduction.Molecules (Basel, Switzerland) · 2019Review
- Blasticidin-S deaminase, a new selection marker for genetic transformation of the diatomPeerJ · 2018Article
- Brassinosteroids Are Master Regulators of Gibberellin Biosynthesis in Arabidopsis.The Plant cell · 2015Article
- Consequences of induced brassinosteroid deficiency in Arabidopsis leaves.BMC plant biology · 2014Article
- Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta.BMC plant biology · 2014Article
- Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogens.SpringerPlus · 2014Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Brassinosteroids (BRs) are plant steroid hormones with structural similarity to mammalian sex steroids and ecdysteroids from insects. The BRs are synthesized from sterols and are essential regulators of cell division, cell elongation and cell differentiation. In this work we show that voriconazole, an antifungal therapeutic drug used in human and veterinary medicine, severely impairs plant growth by inhibiting sterol-14α-demethylation and thereby interfering with BR production. The plant growth regulatory properties of voriconazole and related triazoles were identified in a screen for compounds with the ability to alter BR homeostasis. Voriconazole suppressed growth of the model plant Arabidopsis thaliana and of a wide range of both monocotyledonous and dicotyledonous plants. We uncover that voriconazole toxicity in plants is a result of a deficiency in BRs that stems from an inhibition of the cytochrome P450 CYP51, which catalyzes a step of BR-dependent sterol biosynthesis. Interestingly, we found that the woodland strawberry Fragaria vesca, a member of the Rosaceae, is naturally voriconazole resistant and that this resistance is conferred by the specific CYP51 variant of F. vesca. The potential of voriconazole as a novel tool for plant research is discussed.
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Registered trials
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