ArticlePloS one2013
The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Early-life viral infection generates pathological tissue-resident memory cells that contribute to asthma-like disease.JCI insight · 2026Article
- Developmental hematopoiesis: innate programming of αβ T cells.Experimental hematology · 2026Review
- Th1 differentiation and function are inhibited in neonates following human metapneumovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Multiple waves of fetal-derived immune cells constitute adult immune system.Immunological reviews · 2023Review
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Neonatal Immune Responses to Respiratory Viruses.Frontiers in immunology · 2022Review
- Human CD36Immunology · 2021Article
- Preventing Atopic Diseases During Childhood - Early Exposure Matters.Frontiers in immunology · 2021Review
- Modulating local airway immune responses to treat allergic asthma: lessons from experimental models and human studies.Seminars in immunopathology · 2020Review
- Evaluation of the Induction of Cell-Mediated Immunity Against Candida albicans in a Model of Cutaneous Infection in Newborn 0-Day-Old Mice.Mycopathologia · 2019Article
- Polyphenol Effects on Splenic Cytokine Response in Post-Weaning Contactin 1-Overexpressing Transgenic Mice.Molecules (Basel, Switzerland) · 2019Article
- Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma.Frontiers in immunology · 2018Review
- Immune responses in neonates.Expert review of clinical immunology · 2014Review
- Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state.Immunologic research · 2013Review
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Authors and funding
4 authors.
Funding
Abstract
Epigenetic modifications play a central role in the differentiation and function of immune cells in adult animals. Developmentally regulated epigenetic patterns also appear to contribute to the ontogeny of the immune system. We show here that the epigenetic profile of the T-helper (Th) 2 locus undergoes changes in T lineage cells beginning in mid-gestation and extending throughout the first week of life. In particular, regulatory regions of the Th2 locus are largely methylated at CpG residues among fetal liver common lymphoid progenitor cells. The locus subsequently becomes highly hypomethylated among the downstream progeny of these cells within the fetal thymus. This hypomethylated state is preserved until birth when the locus becomes rapidly re-methylated, achieving adult-like status by 3-6 days post birth. Notably, the capacity for rapid, high level Th2 cytokine production is lost in parallel with this re-methylation. In vitro organ culture and in vivo transplantation experiments indicate that signals from the adult environment are required to achieve the postnatal methylated state. Together, these findings indicate that the Th2 bias of neonates may be conferred, in part, by an epigenetic profile inherited from fetal life. However, the fetal program is rapidly terminated post birth by the development of signals leading to the acquisition of adult-like epigenetic patterns.
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