ArticleExpert opinion on medical diagnostics2013
Challenges in Biomarker Discovery: Combining Expert Insights with Statistical Analysis of Complex Omics Data.
Article in Expert opinion on medical diagnostics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed.
- A generalizable computational framework for integrating heterogeneous biomarkers into interpretable scalar risk representations.BMC medical informatics and decision making · 2026Article
- Molecular predictors of incident frailty: a systematic review and critical appraisal of longitudinal evidence.GeroScience · 2026Review
- Prognostic biomarker discovery in pancreatic cancer through hybrid ensemble feature selection and multi-omics data.BioData mining · 2026Article
- A Practical Roadmap for Clinical Translation of Metabolic Biomarkers: A Review.International journal of molecular sciences · 2026Review
- Candidate biomarkers to identify mesothelioma patients at risk of developing venous thromboembolism post-surgery.Scientific reports · 2026Article
- CPSM: an R package for cancer patient survival risk model using transcriptomics and clinical data.GigaScience · 2026Article
- New insight into RNA biomarkers in neuropathic pain: a clinician-neuroscientist roadmap to translational testing and treatment monitoring a clinical review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Geometric multidimensional representation of omic signatures.Frontiers in bioinformatics · 2026Article
- Research trends of neoadjuvant therapy for breast cancer: A bibliometric analysis.Human vaccines & immunotherapeutics · 2025Review
- A statistical physics approach to integrating multi-omics data for disease-module detection.Cell reports methods · 2025Article
- Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions.Proteomics. Clinical applications · 2025Review
- Drug Discovery and Development for Heart Failure Using Multi-Omics Approaches.International journal of molecular sciences · 2025Review
- Polymerase Chain Reaction Chips for Biomarker Discovery and Validation in Drug Development.Micromachines · 2025Review
- Potential of plasma biomarkers for heart failure prediction, management, and prognosis: A multiomics perspective.Heart failure reviews · 2025Review
- Article
- Neoadjuvant immunotherapy for dMMR and pMMR colorectal cancers: therapeutic strategies and putative biomarkers of response.Nature reviews. Clinical oncology · 2024Review
- LOCC: a novel visualization and scoring of cutoffs for continuous variables with hepatocellular carcinoma prognosis as an example.BMC bioinformatics · 2024Article
- Nanosensor-Enabled Detection and Identification of Intracellular Bacterial Infections in Macrophages.Biosensors · 2024Article
- Strategies for improving the performance of prediction models for response to immune checkpoint blockade therapy in cancer.BMC research notes · 2024Article
- The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response.Frontiers in pharmacology · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionThe advent of high throughput technologies capable of comprehensive analysis of genes, transcripts, proteins and other significant biological molecules has provided an unprecedented opportunity for the identification of molecular markers of disease processes. However, it has simultaneously complicated the problem of extracting meaningful molecular signatures of biological processes from these complex datasets. The process of biomarker discovery and characterization provides opportunities for more sophisticated approaches to integrating purely statistical and expert knowledge-based approaches. AREAS COVERED: In this review we will present examples of current practices for biomarker discovery from complex omic datasets and the challenges that have been encountered in deriving valid and useful signatures of disease. We will then present a high-level review of data-driven (statistical) and knowledge-based methods applied to biomarker discovery, highlighting some current efforts to combine the two distinct approaches. EXPERT OPINION: Effective, reproducible and objective tools for combining data-driven and knowledge-based approaches to identify predictive signatures of disease are key to future success in the biomarker field. We will describe our recommendations for possible approaches to this problem including metrics for the evaluation of biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.