Evidence map›Paper›PMID 23335899›Full record

ArticleFrontiers in physiology2012

Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells.

Bing-Chen Liu, Xiao-Yu Lu, Xiang Song, Ke-Yu Lei, Abdel A Alli, Hui-Fang Bao, Douglas C Eaton, He-Ping Ma

Abstract read
In one paragraph

Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Scanning Ion Conductance Microscopy.Chemical reviews · 2021
    Review
  6. Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020
    Article
  7. Article
  8. Nanopipette exploring nanoworld.Nano convergence · 2014
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bing-Chen LiuDepartment of Physiology, Emory University School of Medicine Atlanta, GA, USA.
Xiao-Yu Lu
Xiang Song
Ke-Yu Lei
Abdel A Alli
Hui-Fang Bao
Douglas C Eaton
He-Ping Ma

Funding

IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2M
REGULATION OF SODIUM IN TIGHT EPITHELIAR37DK037963 · NIDDK · EMORY UNIVERSITY · PI EATON, DOUGLAS C. · 2002 to 2011
$3.8M
Regulation of ENaC by Anionic PhospholipidsR01DK067110 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MA, HE-PING · 2004 to 2012
$1.6M
NIDDK NIH HHS R01 DK067110NIDDK NIH HHS R37 DK037963NIGMS NIH HHS K12 GM000680
6 · The paper itself

Abstract

Scanning ion-conductance microscope (SICM), which enables high-resolution imaging of cell surface topography, has been developed for over two decades. However, only recently, a unique scanning mode is increasingly used in biological studies to allow SICM to detect the surface of live cells. More recently, in combination with confocal microscopy and patch-clamp electrophysiological techniques, SICM allows investigators to localize proteins or ion channels in a specific nanostructure at the cell surface. This article will briefly review SICM nanotechnique and summarize the role of SICM in biological studies.

Indexed as

ciliaconfocal microscopyendocytic pitslive cell imagingmicrovillinanoscale topographypatch-clamp techniquestight junctions

Identifiers

PMID23335899
PMCPMC3544149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.