ArticleFrontiers in neural circuits2012
Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 214 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial
Who cites it
214 citing papers in PubMed, 8 syntheses or guidelines pooled it, 401 citations in OpenAlex.
- Hidden impacts, visible deficits: a comprehensive systematic literature review of the cognitive impairment in patients with Chiari malformation type I.Neurosurgical review · 2025Pooled it
- Cognition in Chiari Malformation Type I: an Update of a Systematic Review.Neuropsychology review · 2024Pooled it
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Probing cerebellar involvement in cognition through a meta-analysis of TMS evidence.Scientific reports · 2021Pooled it
- Cerebellar Degeneration in Epilepsy: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.Cerebellum (London, England) · 2020Pooled it
- Anomalous Perception of Biological Motion in Autism: A Conceptual Review and Meta-Analysis.Scientific reports · 2020Pooled it
- Pooled it
- Training gains and transfer effects after mnemonic strategy training in mild cognitive impairment: A fMRI study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Trial
- Prefronto-cerebellar neuromodulation affects appetite in obesity.International journal of obesity (2005) · 2019Trial
- What Do We Know About the Influence of the Cerebellum on Walking Ability? Promising Findings from Transcranial Alternating Current Stimulation.Cerebellum (London, England) · 2017Trial
- Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder.Journal of psychiatric research · 2017Trial
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Biochemical Pathways of Neuroplasticity in Sport Skill Acquisition: From Neuroscience to Coaching Practice.Brain sciences · 2026Review
- Possible compensatory role of cerebellum in bipolar disorder. A cortical thickness study.European archives of psychiatry and clinical neuroscience · 2026Article
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID-19 Related Anosmia With a Comprehensive Quantitative MRI Protocol.Journal of magnetic resonance imaging : JMRI · 2026Article
- Differential Impacts of Fronto-Cerebellar tACS and tVNS on Motor Learning: Evidence for Sex-Related Neural Modulation.Neural plasticity · 2026Article
- Cerebellar cognitive affective syndrome (Schmahmann syndrome) following isolated cerebellar infarction.Dementia & neuropsychologia · 2026Article
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following the fundamental recognition of its involvement in sensory-motor coordination and learning, the cerebellum is now also believed to take part in the processing of cognition and emotion. This hypothesis is recurrent in numerous papers reporting anatomical and functional observations, and it requires an explanation. We argue that a similar circuit structure in all cerebellar areas may carry out various operations using a common computational scheme. On the basis of a broad review of anatomical data, it is conceivable that the different roles of the cerebellum lie in the specific connectivity of the cerebellar modules, with motor, cognitive, and emotional functions (at least partially) segregated into different cerebro-cerebellar loops. We here develop a conceptual and operational framework based on multiple interconnected levels (a meta-levels hypothesis): from cellular/molecular to network mechanisms leading to generation of computational primitives, thence to high-level cognitive/emotional processing, and finally to the sphere of mental function and dysfunction. The main concept explored is that of intimate interplay between timing and learning (reminiscent of the "timing and learning machine" capabilities long attributed to the cerebellum), which reverberates from cellular to circuit mechanisms. Subsequently, integration within large-scale brain loops could generate the disparate cognitive/emotional and mental functions in which the cerebellum has been implicated. We propose, therefore, that the cerebellum operates as a general-purpose co-processor, whose effects depend on the specific brain centers to which individual modules are connected. Abnormal functioning in these loops could eventually contribute to the pathogenesis of major brain pathologies including not just ataxia but also dyslexia, autism, schizophrenia, and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.