ArticleFrontiers in cellular neuroscience2012
GABA-B receptors in the PNS have a role in Schwann cells differentiation?
Article in Frontiers in cellular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Peripheral glia diversity.Journal of anatomy · 2022Review
- Peripheral mechanisms of chronic pain.Medical review (2021) · 2022Review
- Schwann cell interactions during the development of the peripheral nervous system.Developmental neurobiology · 2021Review
- Expression and Function of GABA Receptors in Myelinating Cells.Frontiers in cellular neuroscience · 2020Article
- Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 1: peripheral neuropathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination.Molecular neurobiology · 2019Article
- Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination.Frontiers in cellular neuroscience · 2019Review
- Comparative transcriptomic profiling of peripheral efferent and afferent nerve fibres at different developmental stages in mice.Scientific reports · 2018Article
- The adjustment of γ-aminobutyric acidNeural regeneration research · 2018Review
- Unwrapping the unappreciated: recent progress in Remak Schwann cell biology.Current opinion in neurobiology · 2017Review
- Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways.Neural regeneration research · 2017Review
- Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium.The European journal of neuroscience · 2016Article
- Tumor suppressor Nf2/merlin drives Schwann cell changes following electromagnetic field exposure through Hippo-dependent mechanisms.Cell death discovery · 2015Article
- Immunohistochemical evidence of the presence of metabotropic receptors for γ-aminobutyric acid at the rat neuromuscular junctions.Doklady. Biochemistry and biophysics · 2015Article
- Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.Orphanet journal of rare diseases · 2014Article
- Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain.BioMed research international · 2014Article
- Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death.Cell death & disease · 2013Article
- Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.Frontiers in cellular neuroscience · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
γ-aminobutyric acid type B (GABA-B) receptor mediates the inhibitory transmission of γ-aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells (SC) suggesting its contribution in regulating the cell fate, maturation, and plasticity. Here, we further support the functional presence of GABA-B receptor in SC plasma membrane. By confocal microscopy immunofluorescence we provide evidences that GABA-B localization on the cell elongated processes correlates with the morphological changes occurring in the differentiated SC. In vivo most of the GABA-B receptors seem to be present in non-myelinating SC, which are committed to ensheath the nociceptive fibers. Therefore, we argue that GABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating SC, but are also fundamental in regulating the SC plasticity versus the non-myelinating state. Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of SC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.