Evidence map›Paper›PMID 23335803›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2013

The paradoxical functions of B cells and antibodies in transplantation.

Marilia I Cascalho, Brian J Chen, Mandy Kain, Jeffrey L Platt

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. The five dimensions of B cell tolerance.Immunological reviews · 2019
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. B cells in transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2016
    Article
  18. Review
  19. Article
  20. Heparan Sulfate Proteoglycan Metabolism and the Fate of Grafted Tissues.Advances in experimental medicine and biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marilia I CascalhoDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. marilia@umich.edu
Brian J Chen
Mandy Kain
Jeffrey L Platt

Funding

T cell responses and cardiac transplantation in infancyP01HL079067 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2005 to 2009
$6.3M
Xenogeneic Natural Antibody Targets-Structure/FunctionR37HL052297 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2001 to 2010
$3.9M
Elements of B Cell MemoryR01AI048602 · NIAID · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI CASCALHO, MARILIA ISABEL · 2001 to 2005
$1.5M
XENOGENEIC NATURAL ANTIBODY TARGETS--STRUCTURE/FUNCTIONR01HL052297 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI PLATT, JEFFREY L · 1993 to 2000
$319k
NHLBI NIH HHS HL52297NHLBI NIH HHS HL79067NHLBI NIH HHS P01 HL079067NHLBI NIH HHS R01 HL052297NHLBI NIH HHS R37 HL052297NIAID NIH HHS R01 AI048602
6 · The paper itself

Abstract

Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from injury. In this article, we review and discuss this possibility and consider how less well-known functions of B cells and Abs might impact on the design of therapeutics and the management of transplant recipients.

Indexed as

Transplantation ImmunologyAnimalsAntigen PresentationB-LymphocytesCellular MicroenvironmentHistocompatibility AntigensHumansImmunity, CellularIsoantibodiesKidney TransplantationMiceT-LymphocytesHistocompatibility AntigensIsoantibodies

Identifiers

PMID23335803
PMCPMC3555513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.