ArticleNucleic acids research2013
Structure, evolution and function of the bi-directionally transcribed iab-4/iab-8 microRNA locus in arthropods.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Genetic Modification of a Hox Locus Drives Mimetic Color Pattern Variation in a Highly Polymorphic Bumble Bee.Molecular biology and evolution · 2023Article
- Differential microRNA expression, microRNA arm switching, and microRNA:long noncoding RNA interaction in response to salinity stress in soybean.BMC genomics · 2022Article
- Annotation of Hox cluster and Hox cofactor genes in the Asian citrus psyllid,GigaByte (Hong Kong, China) · 2022Article
- Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.PLoS genetics · 2021Article
- There and Back Again: Hox Clusters Use Both DNA Strands.Journal of developmental biology · 2021Review
- Pervasive Selection against MicroRNA Target Sites in Human Populations.Molecular biology and evolution · 2020Article
- Millipede genomes reveal unique adaptations during myriapod evolution.PLoS biology · 2020Article
- A homeotic shift late in development drives mimetic color variation in a bumble bee.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- RNAcentral: a hub of information for non-coding RNA sequences.Nucleic acids research · 2019Article
- Identification and characterization of novel conserved RNA structures in Drosophila.BMC genomics · 2018Article
- The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility.PLoS genetics · 2018Article
- Deep experimental profiling of microRNA diversity, deployment, and evolution across theGenome research · 2018Article
- MicroRNAs regulate the sesquiterpenoid hormonal pathway inProceedings. Biological sciences · 2017Article
- Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution.Journal of integrative bioinformatics · 2017Article
- Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.Mechanisms of development · 2015Review
- Controlled expression of Drosophila homeobox loci using the Hostile takeover system.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- A Burst of miRNA Innovation in the Early Evolution of Butterflies and Moths.Molecular biology and evolution · 2015Article
- The phylogenetic utility and functional constraint of microRNA flanking sequences.Proceedings. Biological sciences · 2015Article
- Article
- Sex-biased expression of microRNAs in Schistosoma mansoni.PLoS neglected tropical diseases · 2013Article
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Authors and funding
6 authors.
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Abstract
In Drosophila melanogaster, the iab-4/iab-8 locus encodes bi-directionally transcribed microRNAs that regulate the function of flanking Hox transcription factors. We show that bi-directional transcription, temporal and spatial expression patterns and Hox regulatory function of the iab-4/iab-8 locus are conserved between fly and the beetle Tribolium castaneum. Computational predictions suggest iab-4 and iab-8 microRNAs can target common sites, and cell-culture assays confirm that iab-4 and iab-8 function overlaps on Hox target sites in both fly and beetle. However, we observe key differences in the way Hox genes are targeted. For instance, abd-A transcripts are targeted only by iab-8 in Drosophila, whereas both iab-4 and iab-8 bind to Tribolium abd-A. Our evolutionary and functional characterization of a bi-directionally transcribed microRNA establishes the iab-4/iab-8 system as a model for understanding how multiple products from sense and antisense microRNAs target common sites.
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