Evidence map›Paper›PMID 23335674›Full record

ReviewIEEE reviews in biomedical engineering2013

Fluorescence imaging in surgery.

Ryan K Orosco, Roger Y Tsien, Quyen T Nguyen

Open access · greenAbstract readReview
In one paragraph

Review in IEEE reviews in biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. The Evolution of Fluorescence-Guided Surgery.Molecular imaging and biology · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ryan K OroscoDivision of Head and Neck Surgery, University of California San Diego, La Jolla, CA 92093-0647, USA.
Roger Y Tsien
Quyen T Nguyen
University of California, San Diego · USHoward Hughes Medical Institute · US

Funding

DEVELOPMENT OF CEREBRAL SPECIALIZATIONSR01DC000128 · NIDCD · UNIVERSITY OF OREGON · PI NEVILLE, HELEN JUNE · 1989 to 2011
$6.0M
Injectable reporters to image tumors and guide resectionR01CA158448 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, QUYEN · 2011 to 2015
$3.1M
OTOLARYNGOLOGY TRAINING IN IMMUN., VIROL. &MOLEC. BIOL.T32DC000028 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 1989 to 2020
$2.1M
Testing Fluorescently Labeled Probes for Nerve Imaging during SurgeryR01EB014929 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, QUYEN · 2012 to 2016
$1.7M
LANGUAGE-BASED MEMORY AND SPATIAL MEMORY IN THE DEAFF32DC000128 · NIDCD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WILSON, MARGARET L · 1993 to 1996
–
Howard Hughes Medical InstituteNCI NIH HHS R01 CA158448NIBIB NIH HHS R01 EB014929NIBIB NIH HHS R01 EB014929-01NIDCD NIH HHS F32 DC000128NIDCD NIH HHS R01 DC000128NIDCD NIH HHS T32 DC000028NIDCD NIH HHS T32 DC000128Wellcome Trust
6 · The paper itself

Abstract

Although the modern surgical era is highlighted by multiple technological advances and innovations, one area that has remained constant is the dependence of the surgeon's vision on white-light reflectance. This renders different body tissues in a limited palette of various shades of pink and red, thereby limiting the visual contrast available to the operating surgeon. Healthy tissue, anatomic variations, and diseased states are seen as slight discolorations relative to each other and differences are inherently limited in dynamic range. In the upcoming years, surgery will undergo a paradigm shift with the use of targeted fluorescence imaging probes aimed at augmenting the surgical armamentarium by expanding the "visible" spectrum available to surgeons. Such fluorescent "smart probes" will provide real-time, intraoperative, pseudo-color, high-contrast delineation of both normal and pathologic tissues. Fluorescent surgical molecular guidance promises another major leap forward to improve patient safety and clinical outcomes, and to reduce overall healthcare costs. This review provides an overview of current and future surgical applications of fluorescence imaging in diseased and nondiseased tissues and focus on the innovative fields of image processing and instrumentation.

Indexed as

AnimalsFluorescenceFluorescent DyesHumansMolecular ImagingOptical ImagingSurgery, Computer-AssistedFluorescent Dyes

Identifiers

PMID23335674
PMCPMC3762450
OpenAlexW1994547831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.