ArticleToxicological sciences : an official journal of the Society of Toxicology2013
Hypoxia stress test reveals exaggerated cardiovascular effects in hypertensive rats after exposure to the air pollutant acrolein.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- How people think about the chemicals in cigarette smoke: a systematic review.Journal of behavioral medicine · 2017Pooled it
- Correlation of exposure to volatile organic compounds with myocardial infarction: A Cross-sectional study based on NHANES 2011-2018.Scientific reports · 2025Article
- Volatile organic compounds exposure in relation to glucose homeostasis and type 2 diabetes in older adults from the NHANES.Scientific reports · 2024Article
- Fossil-fuel and combustion-related air pollution and hypertension in the Sister Study.Environmental pollution (Barking, Essex : 1987) · 2022Article
- Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.Environmental research · 2021Article
- A single exposure to eucalyptus smoke sensitizes rats to the postprandial cardiovascular effects of a high carbohydrate oral load.Inhalation toxicology · 2020Article
- Cardiac toxicity of acrolein exposure in embryonic zebrafish (Danio rerio).Environmental science and pollution research international · 2020Article
- TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein.Toxicology and applied pharmacology · 2017Article
- Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses.Cardiovascular toxicology · 2017Article
- Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1.Annals of the New York Academy of Sciences · 2016Review
- Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation.Free radical research · 2016Review
- Xenobiotic pulmonary exposure and systemic cardiovascular response via neurological links.American journal of physiology. Heart and circulatory physiology · 2015Review
- Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats.Particle and fibre toxicology · 2015Article
- Molecular mechanisms of acrolein toxicity: relevance to human disease.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats.Inhalation toxicology · 2015Article
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8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Exposure to air pollution increases the risk of cardiovascular morbidity and mortality, especially in susceptible populations. Despite increased risk, adverse responses are often delayed and require additional stress tests to reveal latent effects of exposure. The goal of this study was to use an episode of "transient hypoxia" as an extrinsic stressor to uncover latent susceptibility to environmental pollutants in a rodent model of hypertension. We hypothesized that exposure to acrolein, an unsaturated aldehyde and mucosal irritant found in cigarette smoke, diesel exhaust, and power plant emissions, would increase cardiopulmonary sensitivity to hypoxia, particularly in hypertensive rats. Spontaneously hypertensive and Wistar Kyoto (normotensive) rats, implanted with radiotelemeters, were exposed once for 3h to 3 ppm acrolein gas or filtered air in whole-body plethysmograph chambers and challenged with a 10% oxygen atmosphere (10min) 24h later. Acrolein exposure increased heart rate, blood pressure, breathing frequency, and minute volume in hypertensive rats and also increased the heart rate variability parameter LF, suggesting a potential role for increased sympathetic tone. Normotensive rats only had increased blood pressure during acrolein exposure. The hypoxia stress test after acrolein exposure revealed increased diastolic blood pressure only in hypertensive rats and increased minute volume and expiratory time only in normotensive rats. These results suggest that hypertension confers exaggerated sensitivity to air pollution and that the hypoxia stress test is a novel tool to reveal the potential latent effects of air pollution exposure.
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