Evidence map›Paper›PMID 23335473›Full record

SynthesisBMJ (Clinical research ed.)2013

Early interventions to prevent psychosis: systematic review and meta-analysis.

Megan R Stafford, Hannah Jackson, Evan Mayo-Wilson, Anthony P Morrison, Tim Kendall

Erratum issued Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04799717 (Game-based Telehealth Therapeutic Intervention in First Onset Psychosis), which is not on this map. Cited by 167 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 19 pooled it
36.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04799717 completednot on this mapstarted 2021, after this paper: background citation

Game-based Telehealth Therapeutic Intervention in First Onset Psychosis

TypeobservationalSponsorStanford UniversityRan2021 to 2022Enrolled8ConditionsPsychotic Disorders, Schizophrenia Spectrum DisordersArmsGaming session
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 19 syntheses or guidelines pooled it, 431 citations in OpenAlex.

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  2. Quality of life in individuals at clinical high risk for psychosis: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2026
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Megan R StaffordNational Collaborating Centre for Mental Health, Royal College of Psychiatrists, London, UK. tim.kendall@shsc.nhs.uk
Hannah Jackson
Evan Mayo-Wilson
Anthony P Morrison
Tim Kendall
Centre for Mental Health · GBSheffield Health and Social Care NHS Foundation Trust · GBUniversity College London · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether any psychological, pharmacological, or nutritional interventions can prevent or delay transition to psychotic disorders for people at high risk.

designSystematic review and meta-analysis. DATA SOURCES: Embase, Medline, PreMedline, PsycINFO, and CENTRAL were searched to November 2011 without restriction to publication status. REVIEW

methodsRandomised trials comparing any psychological, pharmacological, nutritional, or combined intervention with usual services or another treatment. Studies of participants with a formal diagnosis of schizophrenia or bipolar disorder were excluded. Studies were assessed for bias, and relevant limitations were considered in summarising the results.

results11 trials including 1246 participants and eight comparisons were included. Median sample size of included trials was 81 (range 51-288). Meta-analyses were performed for transition to psychosis, symptoms of psychosis, depression, and mania; quality of life; weight; and discontinuation of treatment. Evidence of moderate quality showed an effect for cognitive behavioural therapy on reducing transition to psychosis at 12 months (risk ratio 0.54 (95% confidence interval 0.34 to 0.86); risk difference -0.07 (-0.14 to -0.01). Very low quality evidence for omega-3 fatty acids and low to very low quality evidence for integrated psychotherapy also indicated that these interventions were associated with reductions in transition to psychosis at 12 months.

conclusionsAlthough evidence of benefits for any specific intervention is not conclusive, these findings suggest that it might be possible to delay or prevent transition to psychosis. Further research should be undertaken to establish conclusively the potential for benefit of psychological interventions in the treatment of people at high risk of psychosis.

Indexed as

Antipsychotic AgentsClinical Trials as TopicCognitive Behavioral TherapyCombined Modality TherapyDietary SupplementsEarly DiagnosisFatty Acids, Omega-3HumansPsychotic DisordersRisk FactorsAntipsychotic AgentsFatty Acids, Omega-3

Identifiers

PMID23335473
PMCPMC3548617
OpenAlexW2024581069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.