ArticleJournal of bacteriology2013
Effects of H2 and formate on growth yield and regulation of methanogenesis in Methanococcus maripaludis.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Hypophosphite Is a Naturally Occurring Selective Inhibitor of Syntrophic Methanogenesis.Environmental science & technology · 2026Article
- Article
- Real time monitoring of hydrogenotrophic methanogenesis under deep saline aquifers conditions.Journal of biological engineering · 2026Article
- Key role of hydrogen in regulating hydrogenases and the reductive TCA cycle in a thermophilic, autotrophic sulfur-reducing bacterium.Applied and environmental microbiology · 2025Article
- Cultivation of Methanonezhaarchaeia, the third class of methanogens within the phylum Thermoproteota.Science advances · 2025Article
- Energetic investigations of Acidianus ambivalens metabolism during anaerobic sulfur reduction and comparisons to aerobic sulfur oxidation.Extremophiles : life under extreme conditions · 2025Article
- A promoter-RBS library for fine-tuning gene expression inApplied and environmental microbiology · 2024Article
- An improved CRISPR and CRISPR interference (CRISPRi) toolkit for engineering the model methanogenic archaeon Methanococcus maripaludis.Microbial cell factories · 2024Article
- Bioenergetic characterization of hyperthermophilic archaean Methanocaldococcus sp. FS406-22.Extremophiles : life under extreme conditions · 2024Article
- Functionally redundant formate dehydrogenases enable formate-dependent growth in Methanococcus maripaludis.The Journal of biological chemistry · 2024Article
- Formate and hydrogen in hydrothermal vents and their use by extremely thermophilic methanogens and heterotrophs.Frontiers in microbiology · 2023Review
- CRISPR-Cas9 Toolkit for Genome Editing in an Autotrophic COMicrobiology spectrum · 2022Article
- The Fluorescence-Activating and Absorption-Shifting Tag (FAST) Enables Live-Cell Fluorescence Imaging of Methanococcus maripaludis.Journal of bacteriology · 2022Article
- Scale-up of biomass production byFrontiers in microbiology · 2022Article
- Formate-Dependent Heterodisulfide Reduction in aApplied and environmental microbiology · 2021Article
- Fluid geochemistry, local hydrology, and metabolic activity define methanogen community size and composition in deep-sea hydrothermal vents.The ISME journal · 2019Article
- Growth Kinetics, Carbon Isotope Fractionation, and Gene Expression in the HyperthermophileApplied and environmental microbiology · 2019Article
- On the Edge of Research and Technological Application: A Critical Review of Electromethanogenesis.International journal of molecular sciences · 2017Review
- Application of meta-omics techniques to understand greenhouse gas emissions originating from ruminal metabolism.Genetics, selection, evolution : GSE · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hydrogenotrophic methanogenic Archaea are defined by an H2 requirement for growth. Despite this requirement, many hydrogenotrophs are also capable of growth with formate as an electron donor for methanogenesis. While certain responses of these organisms to hydrogen availability have been characterized, responses to formate starvation have not been reported. Here we report that during continuous culture of Methanococcus maripaludis under defined nutrient conditions, growth yields relative to methane production decreased markedly with either H2 excess or formate excess. Analysis of the growth yields of several mutants suggests that this phenomenon occurs independently of the storage of intracellular carbon or a transcriptional response to methanogenesis. Using microarray analysis, we found that the expression of genes encoding coenzyme F420-dependent steps of methanogenesis, including one of two formate dehydrogenases, increased with H2 starvation but with formate occurred at high levels regardless of limitation or excess. One gene, encoding H2-dependent methylene-tetrahydromethanopterin dehydrogenase, decreased in expression with either H2 limitation or formate limitation. Expression of genes for the second formate dehydrogenase, molybdenum-dependent formylmethanofuran dehydrogenase, and molybdenum transport increased specifically with formate limitation. Of the two formate dehydrogenases, only the first could support growth on formate in batch culture where formate was in excess.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.